ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Biological Mechanisms of Sleep/Wake-Related Function.Biological psychiatry · 2025Review
- Adenosinergic Modulation of Layer 6 Microcircuitry in the Medial Prefrontal Cortex Is Specific to Presynaptic Cell Type.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Effects of adenosine receptor overexpression and silencing in neurons and glial cells on lifespan, fitness, and sleep of Drosophila melanogaster.Experimental brain research · 2023Article
- The role of PHOX2B-derived astrocytes in chemosensory control of breathing and sleep homeostasis.The Journal of physiology · 2019Article
- The Neurobiological Basis of Sleep and Sleep Disorders.Physiology (Bethesda, Md.) · 2018Review
- Adenosine Differentially Modulates Synaptic Transmission of Excitatory and Inhibitory Microcircuits in Layer 4 of Rat Barrel Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Role for neuronal nitric oxide synthase in sleep homeostasis and arousal.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Adenosine A(1) receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release.Anesthesiology · 2013Article
- Article
- Control of sleep and wakefulness.Physiological reviews · 2012Review
- Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons.Journal of neurophysiology · 2012Article
- Adenosine: front and center in linking nutrition and metabolism to neuronal activity.The Journal of clinical investigation · 2011Article
- Article
- Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine.Journal of Alzheimer's disease : JAD · 2010Review
- Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Adenosine and sleep.Current neuropharmacology · 2009Article
- Control and function of the homeostatic sleep response by adenosine A1 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The laterodorsal tegmentum (LDT) neurons supply most of the cholinergic tone to the brainstem and diencephalon necessary for physiological arousal. It is known that application of adenosine in the LDT nucleus increases sleep in vivo (Portas et al., 1997) and directly inhibits LDT neurons in vitro by activating postsynaptic adenosine A(1) receptors (Rainnie et al., 1994). However, adenosine effects on synaptic inputs to LDT neurons has not been previously reported. We found that both evoked glutamatergic EPSCs and GABAergic IPSCs were reduced by adenosine (50 micrometer). A presynaptic site of action for adenosine A(1) receptors on glutamatergic afferents was suggested by the following: (1) adenosine did not affect exogenous glutamate-mediated current, (2) adenosine reduced glutamatergic miniature EPSC (mEPSC) frequency, without affecting the amplitude, and (3) inhibition of the evoked EPSC was mimicked by the A(1) agonist N6-cyclohexyladenosine (100 nm) but not by the A(2) agonist N6-[2-(3,5-dimethoxyphenyl)-2-(methylphenyl)-ethyl]-adenosine (10 nm). The A(1) receptor antagonist 8-cyclopentyltheophylline (CPT; 200 nm) potentiated the evoked EPSCs, suggesting the presence of a tonic activation of presynaptic A(1) receptors by endogenous adenosine. The adenosine kinase inhibitor, 5-iodotubercidin (10 micrometer), mimicked adenosine presynaptic and postsynaptic effects. These effects were antagonized by CPT or adenosine deaminase (0.8 IU/ml), suggesting mediation by increased extracellular endogenous adenosine. Together, these data suggest that the activity of LDT neurons is under inhibitory tone by endogenous adenosine through the activation of both presynaptic A(1) receptors on excitatory terminals and postsynaptic A(1) receptors. Furthermore, an alteration of adenosine kinase activity modifies the degree of this inhibitory tone.
Indexed as
Identifiers
11157094PMC6762335W1740234100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.