ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Elevation of nerve growth factor and antisense knockdown of TrkA receptor during contextual memory consolidation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 69 citations in OpenAlex.
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- Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.Journal of nutritional science · 2018Article
- Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity.AIMS neuroscience · 2016Article
- Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in Middle-Aged Mice.Frontiers in behavioral neuroscience · 2016Article
- Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory.Neuropharmacology · 2015Article
- Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats.Journal of natural medicines · 2011Article
- NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.Brain pathology (Zurich, Switzerland) · 2010Article
- Noradrenaline activation of neurotrophic pathways protects against neuronal amyloid toxicity.Journal of neurochemistry · 2010Article
- Immunohistochemical evaluation of the protein expression of nerve growth factor and its TrkA receptor in rat limbic regions following electroshock seizures.Neuroscience research · 2009Article
- NGF is essential for hippocampal plasticity and learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors.Sports medicine (Auckland, N.Z.) · 2008Review
- Short- and long-term memory are differentialy modulated by hippocampal nerve growth factor and fibroblast growth factor.Neurochemical research · 2005Article
- Effect of electroacupuncture on TRPM7 mRNA expression after cerebral ischemia/reperfusion in rats via TrkA pathway.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2005Article
- Leverpress escape/avoidance training increases neurotrophin levels in rat brain.Integrative physiological and behavioral science : the official journal of the Pavlovian SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We report here a series of experiments establishing a role for nerve growth factor and its high-affinity receptor TrkA in contextual memory consolidation. In all experiments, we trained rats in a novel chamber using tone and shock. Our first experiment revealed that endogenous nerve growth factor (NGF) increases in the hippocampus at a critical time during consolidation that occurs 1 week after training. NGF levels at other intervals (24 hr and 2 and 4 weeks after training) did not differ from those of naive control animals. In our second experiment, we blocked effects that NGF has at 1 week after training by infusing antisense TrkA phosphorothioate DNA oligonucleotide. Reduction of septohippocampal TrkA receptor expression selectively impaired memory consolidation for context but not for tone. Animals with antisense TrkA oligonucleotide infused into the medial septal area or CA1 of the hippocampus froze less when placed in the training chamber than did animals infused with inactive randomized oligonucleotide. At 4 weeks after training, antisense TrkA oligonucleotide had no effect on freezing. Third, we correlated levels of freezing with choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) immunohistochemistry. Antisense TrkA infused into CA1 of the hippocampus reduced cell body cross-sectional area for cholinergic cells in the medial septal area and decreased the density of hippocampal terminals labeled for ChAT and VAChT proteins. Cholinergic cell body measurements were significantly correlated with freezing. Taken together, these results indicate a role for nerve growth factor acting via the TrkA receptor on ChAT and VAChT proteins in contextual memory consolidation.
Indexed as
Identifiers
11157090PMC6762334W1953359380What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.