ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell-like cells in adult mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear.Hearing research · 2020Article
- MicroRNAs and Presbycusis.Aging and disease · 2018Review
- Regeneration of hair cells in the mammalian vestibular system.Frontiers of medicine · 2016Review
- A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".Hearing research · 2013Review
- Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Over half the hair cells in the mouse utricle first appear after birth, with significant numbers originating from early postnatal mitotic production in peripheral and striolar growth zones.Journal of the Association for Research in Otolaryngology : JARO · 2012Article
- The myc road to hearing restoration.Cells · 2012Article
- In vivo proliferative regeneration of balance hair cells in newborn mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- MicroRNAs in inner ear biology and pathogenesis.Hearing research · 2012Review
- EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.Developmental biology · 2012Article
- Concise review: Inner ear stem cells--an oxymoron, but why?Stem cells (Dayton, Ohio) · 2012Review
- S phase entry of neural progenitor cells correlates with increased blood flow in the young subventricular zone.PloS one · 2012Article
- In vitro cultured primary cells from a human utricle explant possesses hair cell like characteristics.Journal of molecular histology · 2011Article
- Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression.PloS one · 2011Article
- Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation.PloS one · 2010Article
- cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.Journal of the Association for Research in Otolaryngology : JARO · 2010Article
- The challenge of hair cell regeneration.Experimental biology and medicine (Maywood, N.J.) · 2010Review
- Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds.The Journal of comparative neurology · 2008Article
- Recent advances in hair cell regeneration research.Current opinion in otolaryngology & head and neck surgery · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the ears of mammals, hair cell loss results in permanent hearing and balance deficits, whereas in fish, amphibians, and birds, the production of replacement hair cells can restore those modalities. In avian ears, continuous exposures to forskolin trigger cell proliferation and the regeneration of hair cells, so we investigated the effect of forskolin on sensory epithelia cultured from the ears of mammals. Continuous 72 hr exposures to forskolin failed to induce proliferation in neonatal rat utricles, but brief (</=1 hr) exposures to forskolin or Br-cAMP did. Proliferation occurred only in media that contained serum. Forskolin also augmented the mitogenic effects of glial growth factor 2. The S-phase entry induced by forskolin was blocked by monensin and bafilomycin, two compounds that can inhibit the recycling of membrane receptors. The results are consistent with the hypothesis that in mammalian vestibular epithelia elevated cAMP induces S-phase entry by increasing the number of growth factor receptors at the plasma membrane.
Indexed as
Identifiers
11157083PMC6762301W1480092883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.