ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Synaptically driven calcium transients via nicotinic receptors on somatic spines.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- The role of teichoic acids of bifidobacteria in driving the interaction with the human host.Frontiers in microbiology · 2025Article
- Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: a narrative review.Annals of translational medicine · 2021Review
- Nicotine Increases Spontaneous Glutamate Release in the Rostromedial Tegmental Nucleus.Frontiers in neuroscience · 2020Article
- Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.Molecular pharmacology · 2013Article
- Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.The Journal of physiology · 2011Article
- Article
- Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses.Molecular and cellular neurosciences · 2010Article
- Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system.Acta pharmacologica Sinica · 2009Review
- EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons.Molecular and cellular neurosciences · 2008Article
- Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors.Biochemical pharmacology · 2007Review
- Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.The Journal of physiology · 2007Article
- Evidence for ectopic neurotransmission at a neuronal synapse.Science (New York, N.Y.) · 2005Article
- Nicotinic acetylcholine receptors at glutamate synapses facilitate long-term depression or potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse.The Journal of physiology · 2005Article
- Rapid activity-driven SNARE-dependent trafficking of nicotinic receptors on somatic spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Nicotine enhancement of dopamine release by a calcium-dependent increase in the size of the readily releasable pool of synaptic vesicles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic spines commonly receive glutamatergic innervation at postsynaptic densities and compartmentalize calcium influx arising from synaptic signaling. Recently, it was shown that a class of nicotinic acetylcholine receptors containing alpha7 subunits is concentrated on somatic spines emanating from chick ciliary ganglion neurons. The receptors have a high relative calcium permeability and contribute importantly to synaptic currents, although they appear to be excluded from postsynaptic densities. Here we show that low-frequency synaptic stimulation of the alpha7-containing receptors induces calcium transients confined to the spines. High-frequency stimulation induces a transient calcium elevation in the spines and a more sustained cell-wide elevation. The high-frequency transient elevation again depends on alpha7-containing receptors, whereas the sustained elevation can be triggered by other nicotinic receptors and depends on calcium release from internal stores and probably influx through voltage-gated L-type calcium channels as well. Retrograde axonal stimulation of the neurons at high frequency mimics synaptic stimulation in producing sustained cell-wide calcium increases that depend on L-type channels and release from internal stores, but it does not produce calcium transients in the spines. Thus frequent action potentials are sufficient to generate the cell-wide increases, but alpha7-containing receptors are needed for spine-specific effects. Patch-clamp recording indicates that alpha7-containing receptors preferentially desensitize at high-frequency stimulation, accounting for the inability of the stimulation to sustain high calcium levels in the spines. The spatial and temporal differences in the patterns of calcium elevation could enable the neurons to monitor their own firing histories for regulatory purposes.
Indexed as
Identifiers
11157063PMC6762332W2111117071What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.