ArticleThe Journal of experimental medicine2001
Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Themis differentially regulates T follicular helper cell differentiation during early and late stages of chronic viral infection.Frontiers in immunology · 2025Article
- Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B.Science advances · 2022Article
- The pursuit of transplantation tolerance: new mechanistic insights.Cellular & molecular immunology · 2019Article
- Human Monoclonal Antibodies as Adjuvant Treatment of Chronic Hepatitis B Virus Infection.Frontiers in immunology · 2019Article
- Article
- Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.Frontiers in immunology · 2016Article
- Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection.Journal of virology · 2014Article
- CD4 T cell responses in latent and chronic viral infections.Frontiers in immunology · 2013Article
- Modeling the adaptive immune response in HBV infection.Journal of mathematical biology · 2011Article
- Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells.The Journal of experimental medicine · 2011Article
- Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children.The Journal of infectious diseases · 2011Article
- Article
- Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B.World journal of gastroenterology · 2008Article
- Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus.Journal of virology · 2007Article
- CD4+ T cell responses in hepatitis C virus infection.World journal of gastroenterology · 2007Review
- Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses.Journal of viral hepatitis · 2006Article
- The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance.PLoS biology · 2006Article
- Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection.The Journal of clinical investigation · 2006Article
- Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have shown previously that neutralizing antibodies (nAbs) are important contributors to the long-term immune control of lymphocytic choriomeningitis virus infection, particularly if cytotoxic T cell responses are low or absent. Nevertheless, virus escape from the nAb response due to mutations within the surface glycoprotein gene may subsequently allow the virus to persist. Here we show that most of the antibody-escape viral mutants retain their immunogenicity. We present evidence that the failure of the infected host to mount effective humoral responses against emerging neutralization-escape mutants correlates with the rapid loss of CD4(+) T cell responsiveness during the establishment of viral persistence. Similar mechanisms may contribute to the persistence of some human pathogens such as hepatitis B and C viruses, and human immunodeficiency virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.