ArticleHeart (British Cardiac Society)2001
Lewis phenotypes, leisure time physical activity, and risk of ischaemic heart disease: an 11 year follow up in the Copenhagen male study.
Article in Heart (British Cardiac Society), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Lack of association between Lewis phenotypes and ischemic heart disease.Sao Paulo medical journal = Revista paulista de medicina · 2012Article
- Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study.American heart journal · 2007Article
- Lewis blood group phenotype vis-a-vis biochemical and physiological parameters of coronary artery disease: A study in North Indian population.Asian journal of transfusion scienceArticle
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test the hypothesis that the predictive value for risk of fatal ischaemic heart disease associated with Lewis phenotypes depends on the level of leisure time physical activity.
designProspective study controlling for alcohol, tobacco, serum cotinine, blood pressure, body mass index, serum lipids, work related physical activity, and social class.
settingThe Copenhagen male study, Denmark. SUBJECTS: 2826 white men aged 53-75 years without overt cardiovascular disease; 266 (9.4%) had the Le(a-b-) phenotype.
main outcome measureIncidence of death from ischaemic heart disease during 11 years.
results107 men died of ischaemic heart disease. Among men with a low level of leisure time physical activity (</= 4 hours/week moderate or </= 2 hours/week more vigorous activity), being Le(a-b-) was associated with an increased risk of having a fatal ischaemic heart disease event compared with men with other Lewis phenotypes (relative risk (RR) 2.7, 95% confidence interval (CI) 1.4 to 5.2; p < 0.01). Among men with a high level of leisure time physical activity, the RR associated with being Le(a-b-) was 1. 3 (95% CI 0.5 to 3.1; NS). Compared with all other alternatives tested, being Le(a-b-) and having a low level of leisure time physical activity was associated with an RR of 3.2 (95% CI 1.7 to 5. 8; p < 0.001). As a point estimate and adjusted for confounding variables, among men with low leisure time physical activity the attributable risk associated with Le(a-b-) was 12%-that is, assuming that all sedentary men had phenotypes other than Le(a-b-), 12% of all fatal ischaemic heart disease events would not have occurred. The corresponding point estimate among those more active was 2%.
conclusionsThe excess risk of fatal ischaemic heart disease in middle aged and elderly men with the Le(a-b-) phenotype is strongly modified by leisure time physical activity. Public health and clinical implications may be important in populations with a predominantly sedentary lifestyle and in a high proportion of men with the Le(a-b-) phenotype.
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