ArticleHeart (British Cardiac Society)2001
Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up.
Article in Heart (British Cardiac Society), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Raising the bar for publication of Mendelian randomisation studies in Diabetologia.Diabetologia · 2025Article
- Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues.European journal of epidemiology · 2020Article
- Serum homocysteine level, vitamin B12 levels, and erythrocyte folate in psoriasis: A case-control study.International journal of women's dermatology · 2019Article
- Allicin improves carotid artery intima-media thickness in coronary artery disease patients with hyperhomocysteinemia.Experimental and therapeutic medicine · 2017Article
- Hyperhomocysteinemia is an independent predictor of sub-clinical carotid vascular damage in subjects with grade-1 hypertension.Endocrine · 2014Article
- Characterization of N-homocysteinylated albumin adducts.The protein journal · 2014Article
- Guanxinkang Decoction Exerts Its Antiatherosclerotic Effect Partly through Inhibiting the Endoplasmic Reticulum Stress.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia.Cardiovascular journal of Africa · 2012Article
- Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health.Genes & nutrition · 2011Article
- Homocysteine levels in chronic gastritis and other conditions: relations to incident cardiovascular disease and dementia.Digestive diseases and sciences · 2010Article
- Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology?Human genetics · 2008Review
- Capitalizing on Mendelian randomization to assess the effects of treatments.Journal of the Royal Society of Medicine · 2007Review
- Mitochondrial mechanism of microvascular endothelial cells apoptosis in hyperhomocysteinemia.Journal of cellular biochemistry · 2006Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProspective assessment of the risk of coronary heart disease associated with total serum homocyst(e)ine (homocysteine) concentration.
designNested case-control study.
settingCaerphilly and surrounding villages in south Wales, UK.
participants2290 men who participated in phase II of the study in 1984. After a mean follow up of 10 years, 312 men developed coronary heart disease and were compared with 1248 randomly selected, age frequency matched controls.
main outcome measureAcute myocardial infarction or death from coronary heart disease.
resultsThe geometric mean serum homocysteine concentration was higher in cases (12.2 micromol/l, 95% confidence interval (CI) 11.8 to 12.6 micromol/l) than in controls (11.8 micromol/l, 95% CI 11.3 to 12.5 micromol/l) (p = 0.09). There was a graded increase in the odds ratio of coronary heart disease across quintiles of the homocysteine concentration distribution compared with the first (p = 0.04), which was attenuated when adjusted for confounding variables (p = 0.4). There was a small but non-significant increase in the adjusted odds ratio of coronary heart disease per standard deviation change in the log distribution of homocysteine concentration (OR = 1.07 (95% CI.93 to 1.24), p = 0.34). Comparing the top quintile of the homocysteine concentration with the remaining 80%, the adjusted odds ratio of coronary heart disease was 1.03 (95% CI 0.73 to 1.45) (p = 0.8) and comparing the top 5% with the remaining 95% it was 1.05 (95% CI 0.56 to 1.95) (p = 0.9).
conclusionsThese findings do not support the hypothesis that a raised homocysteine concentration is a strong independent risk factor for coronary heart disease. Randomised controlled trials of homocysteine lowering treatment such as folic acid are needed before generalizing the early positive results of observational studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.