ArticleAnnals of the rheumatic diseases2001
Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines.
Article in Annals of the rheumatic diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage.The Journal of biological chemistry · 2013Trial
- Optimized Centrifugation and Activation Protocol for the Preparation of Plasma Rich in Growth Factors in Pigs.Biomedicines · 2026Article
- Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models.Disease models & mechanisms · 2024Article
- Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.Osteoarthritis and cartilage open · 2020Article
- Chronic exposure of interleukin-13 suppress the induction of matrix metalloproteinase-1 by tumour necrosis factor α in normal and scleroderma dermal fibroblasts through protein kinase B/Akt.Clinical and experimental immunology · 2018Article
- Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes.PloS one · 2018Article
- Article
- Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.The Journal of biological chemistry · 2017Article
- Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.Tissue engineering. Part A · 2016Article
- Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes.Arthritis research & therapy · 2014Article
- Extracellular and intracellular mechanisms of mechanotransduction in three-dimensionally embedded rat chondrocytes.PloS one · 2014Article
- Protective effects of interleukin-4 on tissue destruction and morphological changes of bovine nasal chondrocytes in vitro.Iranian biomedical journal · 2013Article
- Article
- Combination effects of prednisolone and interleukin-4 protect bovine nasal cartilage explants from interleukin-1α induced degradation.Iranian biomedical journal · 2011Article
- Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.The Journal of biological chemistry · 2010Article
- Cells of the synovium in rheumatoid arthritis. Chondrocytes.Arthritis research & therapy · 2007Review
- Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.Arthritis research & therapy · 2006Article
- Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.Annals of the rheumatic diseases · 2005Article
- Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.Arthritis research & therapy · 2005Article
- Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.The American journal of pathology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether interleukin 13 (IL13) could act in a chondroprotective manner and protect cartilage stimulated to resorb with a combination of IL1alpha and oncostatin M (OSM), in a similar way to the anti-inflammatory cytokine, IL4.
methodsIL13 was added to explant cultures of bovine nasal cartilage stimulated to resorb with IL1alpha and OSM, and the release of collagen and proteoglycan determined. Collagenolytic and tissue inhibitors of metalloproteinase (TIMP) activities were determined by bioassay. Northern blot analyses were performed to determine the effects of IL13 on the induction of matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13, and TIMP-1 gene expression.
resultsIL13 can prevent the release of collagen from bovine nasal cartilage in a dose dependent manner. This was accompanied by a concomitant decrease in measurable collagenolytic activity in the culture supernates and an increase in TIMP activity. Northern blot analysis showed that IL13 down regulated MMP-3 and MMP-13 levels but up regulated MMP-1 and TIMP-1 gene expression in bovine nasal chondrocytes at 24 hours.
conclusionThis study showed for the first time that IL13 can block collagen release from resorbing cartilage in a similar manner to IL4. This is accompanied by a reduction in detectable collagenolytic activity, a decrease in MMP-3 and MMP-13 mRNA levels, and an up regulation of TIMP-1 expression.
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