ArticleMolecular and cellular biology2001
Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 199 citations in OpenAlex.
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- Evolving precision: rRNA expansion segment 7S modulates translation velocity and accuracy in eukaryal ribosomes.Nucleic acids research · 2024Article
- Oxygen level regulates N-terminal translation elongation of selected proteins through deoxyhypusine hydroxylation.Cell reports · 2022Article
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- Delayed Protein Changes During Seed Germination.Frontiers in plant science · 2021Article
- Stress-Induced Translation Inhibition through Rapid Displacement of Scanning Initiation Factors.Molecular cell · 2020Article
- Proteome reallocation from amino acid biosynthesis to ribosomes enables yeast to grow faster in rich media.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation.The FEBS journal · 2019Article
- Translation Control ofInternational journal of molecular sciences · 2019Review
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- An Autophagy-Independent Role forGenetics · 2018Article
- Generation of ribosome imprinted polymers for sensitive detection of translational responses.Scientific reports · 2017Article
- High-throughput mass spectrometry analysis revealed a role for glucosamine in potentiating recovery following desiccation stress in Chironomus.Scientific reports · 2017Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The global gene expression program that accompanies the adaptation of Saccharomyces cerevisiae to an abrupt transfer from a fermentable to a nonfermentable carbon source was characterized by using a cDNA microarray to monitor the relative abundances and polysomal distributions of mRNAs. Features of the program included a transient reduction in global translational activity and a severe decrease in polysome size of transcripts encoding ribosomal proteins. While the overall translation initiation of newly synthesized and preexisting mRNAs was generally repressed after the carbon source shift, the mRNA encoded by YPL250C was an exception in that it selectively mobilized into polysomes, although its relative abundance remained unchanged. In addition, splicing of HAC1 transcripts, which has previously been reported to occur during accumulation of unfolded proteins in the endoplasmic reticulum, was observed after the carbon shift. This finding suggests that the nonconventional splicing complex, composed of the kinase-endonuclease Ire1p and the tRNA ligase Rlg1p, was activated. While spliced HAC1 transcripts mobilized into polysomes, the vast majority of unspliced HAC1 RNA accumulated in nonpolysomal fractions before and after the carbon source shift, indicating that translation of unspliced HAC1 RNA is blocked at the translation initiation step, in addition to the previously reported elongation step. These findings reveal that S. cerevisiae reacts to the carbon source shift with a remarkable variety of responses, including translational regulation of specific mRNAs and activation of specific enzymes involved in a nonconventional splicing mechanism.
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