ArticleJournal of epidemiology and community health2001
Homocysteine and ischaemic stroke in men: the Caerphilly study.
Article in Journal of epidemiology and community health, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Prognostic Value of Homocysteine in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis.Frontiers in systems neuroscience · 2020Pooled it
- The Multitarget Action of Vitamins in the Ischemic Stroke.Current topics in medicinal chemistry · 2024Review
- Associations between homocysteine, vitamin B12, and folate and the risk of all-cause mortality in American adults with stroke.Frontiers in nutrition · 2023Article
- Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China.Disease markers · 2021Article
- Use of serum homocysteine to predict cardiovascular disease in Korean men with or without metabolic syndrome.Journal of Korean medical science · 2012Article
- Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol.Cardiovascular diabetology · 2010Article
- Plasma homocysteine as a risk factor for strokes in ghanaian adults.Ghana medical journal · 2009Article
- Breast feeding and cardiovascular disease risk factors, incidence, and mortality: the Caerphilly study.Journal of epidemiology and community health · 2005Article
- Health status as a potential effect modifier of the relation between noise annoyance and incidence of ischaemic heart disease.Occupational and environmental medicine · 2003Article
- Management and Prevention of Stroke Associated with Elevated Homocysteine.Current treatment options in cardiovascular medicine · 2002Article
- The role of hydrogen sulfide in stroke.Medical gas researchReview
- H-type hypertension and risk of stroke in chinese adults: A prospective, nested case-control study.Journal of translational internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the risk of ischaemic stroke associated with total serum homocyst(e)ine (tHcy) concentration.
designCohort study.
settingCaerphilly, South Wales
participants2254 men age 50 to 64 years recruited between 1984 and 1988.
results107 men developed ischaemic stroke and mean follow up time was 10.2 years. There was no significant difference in mean serum total homocyst(e)ine levels between stroke cases (12.2 micromol 95% CI 11.6 to 13.1) and non-cases (11.7 micromol 95% CI 11.5 to 11.9) (p=0.14). There was no significant risk for a standard deviation increase in homocyst(e)ine (adjusted hazard ratio = 1.1, 95% CI 0.9 to 1.4). An interaction was observed between homocyst(e)ine and age at entry (p=0.003). The adjusted odds ratio comparing the top quintile of homocyst(e)ine with the rest was 2.5 (95% CI 1.0 to 6.2) for strokes occurring under 65 years and 0.5 (95% CI 0.2 to 1.3) at 65 years or older (p value for interaction =0.02). Risk also differed by blood pressure status. The adjusted hazard ratio for a standard deviation increase in homocyst(e)ine was 0.8, (95% CI 0.6 to 1.2) for normotensive men and 1.3 (95% CI 1.1 to 1.7) for hypertensive men (p value for interaction =0.01).
conclusionsOverall, there is no significant relation between homocyst(e)ine and ischaemic stroke in this cohort. However, its aetiological importance may be greater for premature ischaemic strokes (<65 years) and in hypertensive men.
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