ArticleHuman genetics2000
Association of the TNF-alpha-308 (G-->A) polymorphism with self-reported history of childhood asthma.
Article in Human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Vascular endothelial growth factor -634G/C and vascular endothelial growth factor -2578C/A polymorphisms and lung cancer risk: a case-control study and meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis.Thorax · 2006Pooled it
- An association between asthma and TNF-308G/A polymorphism: meta-analysis.Journal of human genetics · 2006Pooled it
- Gene polymorphisms and chronic obstructive pulmonary disease.Journal of cellular and molecular medicine · 2014Article
- Tumour necrosis factor gene polymorphism and disease prevalence.Scandinavian journal of immunology · 2011Review
- Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population.Pediatric allergy, immunology, and pulmonology · 2011Article
- Association between β+252 tumour necrosis factor polymorphism and asthma in western Saudi children.Saudi journal of biological sciences · 2011Article
- Unifying candidate gene and GWAS Approaches in Asthma.PloS one · 2010Article
- Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population.Reproductive biology and endocrinology : RB&E · 2010Article
- Association of tumor necrosis factor-alpha -308G>A polymorphism with IgE-mediated allergy to betalactams in an Italian population.The pharmacogenomics journal · 2008Article
- Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.Environmental health perspectives · 2007Article
- Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.American journal of respiratory and critical care medicine · 2006Article
- TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences.American journal of respiratory and critical care medicine · 2005Article
- Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes.American journal of respiratory and critical care medicine · 2005Article
- Is there a future for TNF promoter polymorphisms?Genes and immunity · 2004Review
- Association of -238G/A polymorphism of tumor necrosis factor-alpha gene promoter region with outcomes of hepatitis B virus infection in Chinese Han population.World journal of gastroenterology · 2004Article
- Effect of TNF and LTA polymorphisms on biological markers of response to oxidative stimuli in coal miners: a model of gene-environment interaction. Tumour necrosis factor and lymphotoxin alpha.Journal of medical genetics · 2003Article
- Association studies for asthma and atopic diseases: a comprehensive review of the literature.Respiratory research · 2003Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a complex disease involving genetic and environmental aetiology. The tumour necrosis factor-alpha (TNF-alpha) and angiotensin-converting enzyme (ACE) genes have been implicated in asthma pathogenesis. This study investigated the association of a G-308A variant of TNF-alpha and an insertion/deletion (I/D) variant of ACE with a self-reported history of childhood asthma, in two population groups. At Northwick Park Hospital, London, 1,811 pregnant women attending for antenatal care were recruited. Participants with a self-reported history of childhood asthma, determined by a researcher-administered questionnaire, and controls with no personal or family history of asthma, of UK/Irish (cases n=20; controls n=416) and South Asian (cases n=6; controls n=275) origin were used in this study. Participants were genotyped for the TNF-alpha-308 and ACE I/D variants by a PCR-RFLP and PCR approach. The TNF-alpha-308 allele 2 (-308A) was significantly associated with self-reported childhood asthma in the UK/Irish (Odds ratios (OR): 2.6; 95% confidence intervals (CI): 1.1-6.2; P=0.03) but not in the South Asian population. The ACE DD genotype was not associated with childhood asthma in either population group. Gametic phase disequilibrium between the TNF-alpha-308 and ACE I/D variants was significantly different from zero in UK/Irish cases (delta=0.09; P=0.034). The TNF-alpha308 allele 2 or a linked major histocompatibility complex (MHC) variant may be a genetic risk factor for childhood asthma in the UK/Irish sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.