Evidence map›Paper›PMID 11152529›Full record

ArticleJournal of virology2001

Ten-kilodalton domain in Ty3 Gag3-Pol3p between PR and RT is dispensable for Ty3 transposition.

J A Claypool, H S Malik, T H Eickbush, S B Sandmeyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

J A ClaypoolDepartment of Microbiology and Molecular Genetics, University of California, Irvine, California 92697-1700, USA.
H S Malik
T H Eickbush
S B Sandmeyer
Laboratory of Molecular Genetics · PLUniversity of Rochester · US

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Ty3 Viruslike Particle Morphogenesis and Host InteractionsR01GM033281 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 1985 to 2013
$4.7M
NCI NIH HHS T32 CA009054NCI NIH HHS T32 CA09054NIGMS NIH HHS GM33281NIGMS NIH HHS R01 GM033281
6 · The paper itself

Abstract

Ty3 is a gypsy-type, retrovirus-like element found in the budding yeast Saccharomyces cerevisiae. In cells overexpressing Ty3 under the GAL1 upstream activation sequence, Ty3 RNA, proteins, and DNA are made. Elucidation of the molecular masses and amino-terminal sequences of protease and reverse transcriptase indicated the existence of an additional intervening domain, designated J, in the Ty3 Gag3-Pol3p polyprotein. A region analogous to J can be found in many retrotransposable elements closely related to Ty3; however, J does not correspond to any of the highly conserved retroviral protein domains. Ty3 mutants deleted for the J-coding region showed moderately reduced transposition frequency but greatly reduced levels of Ty3 DNA. These results show that under galactose regulation, the Ty3 J domain is not absolutely essential.

Indexed as

Aspartic Acid EndopeptidasesGene Products, gagGene Products, polMolecular WeightRetroelementsRNA-Directed DNA PolymeraseSaccharomyces cerevisiaeAspartic Acid EndopeptidasesGene Products, gagGene Products, polRetroelementsRNA-Directed DNA Polymerase

Identifiers

PMID11152529
PMCPMC114062
OpenAlexW2117410860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.