ArticleJournal of virology2001
Sorting of Marburg virus surface protein and virus release take place at opposite surfaces of infected polarized epithelial cells.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV).Virulence · 2021Article
- Marburg Virus Reverse Genetics Systems.Viruses · 2016Review
- Paramyxovirus glycoprotein incorporation, assembly and budding: a three way dance for infectious particle production.Viruses · 2014Review
- Nipah virus entry and egress from polarized epithelial cells.Journal of virology · 2013Article
- Forty-five years of Marburg virus research.Viruses · 2012Review
- Canine distemper virus matrix protein influences particle infectivity, particle composition, and envelope distribution in polarized epithelial cells and modulates virulence.Journal of virology · 2011Article
- Paramyxovirus assembly and budding: building particles that transmit infections.The international journal of biochemistry & cell biology · 2010Review
- Influenza virus morphogenesis and budding.Virus research · 2009Review
- No exit: targeting the budding process to inhibit filovirus replication.Antiviral research · 2009Review
- Article
- Human respiratory syncytial virus glycoproteins are not required for apical targeting and release from polarized epithelial cells.Journal of virology · 2008Article
- Role of the transmembrane domain of marburg virus surface protein GP in assembly of the viral envelope.Journal of virology · 2007Article
- VP24 of Marburg virus influences formation of infectious particles.Journal of virology · 2005Article
- Assembly and budding of influenza virus.Virus research · 2004Review
- Multivesicular bodies as a platform for formation of the Marburg virus envelope.Journal of virology · 2004Article
- A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus.The Journal of biological chemistry · 2004Article
- Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal.Journal of virology · 2002Article
- Vesicular stomatitis virus glycoprotein does not determine the site of virus release in polarized epithelial cells.Journal of virology · 2002Article
- VP40, the matrix protein of Marburg virus, is associated with membranes of the late endosomal compartment.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marburg virus, a filovirus, causes severe hemorrhagic fever with hitherto poorly understood molecular pathogenesis. We have investigated here the vectorial transport of the surface protein GP of Marburg virus in polarized epithelial cells. To this end, we established an MDCKII cell line that was able to express GP permanently (MDCK-GP). The functional integrity of GP expressed in these cells was analyzed using vesicular stomatitis virus pseudotypes. Further experiments revealed that GP is transported in MDCK-GP cells mainly to the apical membrane and is released exclusively into the culture medium facing the apical membrane. When MDCKII cells were infected with Marburg virus, the majority of GP was also transported to the apical membrane, suggesting that the protein contains an autonomous apical transport signal. Release of infectious progeny virions, however, took place exclusively at the basolateral membrane of the cells. Thus, vectorial budding of Marburg virus is presumably determined by factors other than the surface protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.