ArticleJournal of virology2001
Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
167 citing papers in PubMed, 563 citations in OpenAlex.
- Article
- Autonomous artificial intelligence, scientific research, and human values.AI and ethics · 2026Article
- CRISPR Treatments for AI-Designed Synthetic Viruses: Rapid Programmable Countermeasures for Emerging and Engineered Viruses.Viruses · 2025Review
- The Case for Limiting "Sequences of Concern" to Those with Demonstrated Pathogenic Function.Applied biosafety : journal of the American Biological Safety Association · 2025Article
- Governing Dual-Use Research of Concern in the Life Sciences: United States and Canada Policy Comparative Analysis and Recommendations.Applied biosafety : journal of the American Biological Safety Association · 2025Article
- Optimal vaccination model of airborne infection under variable humidity and demographic heterogeneity for hybrid fractional operator technique.Scientific reports · 2025Article
- Article
- Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors.Scientific reports · 2025Article
- Genomic variability and immunological aspects involved in response to MPXV infection.Frontiers in pharmacology · 2025Review
- Awareness of the dual-use dilemma in scientific research: reflections and challenges to Latin America.Frontiers in bioengineering and biotechnology · 2025Article
- Reverse Genetics-Based Methodology for Molecular Virology Study.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Cyberbiosecurity: Advancements in DNA-based information security.Biosafety and health · 2024Review
- The Epistemic Value of Gain of Function Experiments.mSphere · 2024Article
- Virology-the path forward.Journal of virology · 2024Article
- Article
- Grand challenge in biosafety and biosecurity.Frontiers in bioengineering and biotechnology · 2024Article
- Orthopoxvirus Zoonoses-Do We Still Remember and Are Ready to Fight?Pathogens (Basel, Switzerland) · 2023Review
- History of advances in genetic engineering of viruses before COVID-19 pandemic.Surgical neurology international · 2023Article
- A teachable moment for dual-use.Nature machine intelligence · 2022Article
- Postbiotics Enhance NK Cell Activation in Stress-Induced Mice through Gut Microbiome Regulation.Journal of microbiology and biotechnology · 2022Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic resistance to clinical mousepox (ectromelia virus) varies among inbred laboratory mice and is characterized by an effective natural killer (NK) response and the early onset of a strong CD8(+) cytotoxic T-lymphocyte (CTL) response in resistant mice. We have investigated the influence of virus-expressed mouse interleukin-4 (IL-4) on the cell-mediated response during infection. It was observed that expression of IL-4 by a thymidine kinase-positive ectromelia virus suppressed cytolytic responses of NK and CTL and the expression of gamma interferon by the latter. Genetically resistant mice infected with the IL-4-expressing virus developed symptoms of acute mousepox accompanied by high mortality, similar to the disease seen when genetically sensitive mice are infected with the virulent Moscow strain. Strikingly, infection of recently immunized genetically resistant mice with the virus expressing IL-4 also resulted in significant mortality due to fulminant mousepox. These data therefore suggest that virus-encoded IL-4 not only suppresses primary antiviral cell-mediated immune responses but also can inhibit the expression of immune memory responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.