ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results.European journal of nuclear medicine and molecular imaging · 2010Trial
- Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats.International journal of molecular sciences · 2022Article
- Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience?International journal of molecular sciences · 2021Review
- Chronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala.Frontiers in neuroscience · 2020Article
- Balancing tonic and phasic inhibition in hypothalamic corticotropin-releasing hormone neurons.The Journal of physiology · 2018Article
- Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents.Molecular brain · 2014Article
- Adrenal disorders and the paediatric brain: pathophysiological considerations and clinical implications.International journal of endocrinology · 2014Review
- Long-lasting increase of corticosterone after fear memory reactivation: anxiolytic effects and network activity modulation in the ventral hippocampus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- The GABAergic deficit hypothesis of major depressive disorder.Molecular psychiatry · 2011Article
- gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.Biological psychiatry · 2010Article
- Differential corticosteroid modulation of inhibitory synaptic currents in the dorsal and ventral hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis.Reviews in the neurosciences · 2008Review
- Chronic corticosterone elevation and sex-specific augmentation of the hypoxic ventilatory response in awake rats.The Journal of physiology · 2007Article
- Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration.BMC neuroscience · 2006Article
- Angst and the amygdala.Dialogues in clinical neuroscience · 2006Review
- Escalated aggression as a reward: corticosterone and GABA(A) receptor positive modulators in mice.Psychopharmacology · 2005Article
- Adverse psychological effects of corticosteroids in children and adolescents.Archives of disease in childhood · 2005Review
- Chronic stress enhances ibotenic acid-induced damage selectively within the hippocampal CA3 region of male, but not female rats.Neuroscience · 2004Article
- Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Progesterone withdrawal increases the alpha4 subunit of the GABA(A) receptor in male rats in association with anxiety and altered pharmacology - a comparison with female rats.Neuropharmacology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic stressors produce changes in hippocampal neurochemistry, neuronal morphology, and hippocampal-dependent learning and memory processes. In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission. CORT also alters GABA-mediated inhibitory neurotransmission, so the GABA(A) receptor system may also contribute to dendritic remodeling and other stress-related changes in hippocampal function. A previous study indicated that chronic CORT treatment produces complex changes in GABA(A) receptor subunit mRNA levels, so we hypothesized that CORT alters the pharmacological properties of hippocampal GABA(A) receptors. To test this, adult male rats were treated with CORT or vehicle pellets for 10 d, after which we quantified [(35)S]t-butylbicyclophosphorothionate ([(35)S]TBPS) and [(3)H]flunitrazepam binding to GABA(A) receptors using in vitro receptor autoradiography. Pharmacological properties of receptors were assessed by examining the allosteric regulation of binding at both sites by GABA and 5alpha-pregnane-3alpha,21-diol-20-one (THDOC), an endogenous anxiolytic steroid. We found striking regional differences in the modulation of [(35)S]TBPS binding, particularly between strata radiatum and strata oriens, suggesting a functional heterogeneity among hippocampal GABA(A) receptors even within the apical versus basal dendrites of pyramidal neurons. Furthermore, we found that CORT treatment decreased the negative modulation of hippocampal [(35)S]TBPS binding by both GABA and THDOC and increased the enhancement of [(3)H]flunitrazepam binding by GABA and THDOC in the dentate gyrus. Together, these data suggest that prolonged exposure to stress levels of corticosteroids may alter hippocampal inhibitory tone by regulating the pharmacological properties of GABA(A) receptors in discrete dendritic subfields.
Indexed as
Identifiers
11150350PMC6762424W1905334019What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.