ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- Central amygdalaNeurobiology of stress · 2026Article
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review.Brain sciences · 2024Article
- Prefrontal circuits guiding social preference: Implications in autism spectrum disorder.Neuroscience and biobehavioral reviews · 2022Review
- Molecular Targets of Cannabinoids Associated with Depression.Current medicinal chemistry · 2022Review
- Social defeat: Vagal reduction and vulnerability to ventricular arrhythmias.Neurobiology of stress · 2020Article
- A neuropeptide regulates fighting behavior ineLife · 2020Article
- Blockade of the cholecystokinin CCK-2 receptor prevents the normalization of anxiety levels in the rat.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
- Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus.Frontiers in behavioral neuroscience · 2020Review
- Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression.Molecular psychiatry · 2017Article
- Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Low β2 Main Peak Frequency in the Electroencephalogram Signs Vulnerability to Depression.Frontiers in neuroscience · 2016Article
- Pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST) increases corticosterone in male and female rats.Psychoneuroendocrinology · 2014Article
- Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Involvement of the dorsomedial hypothalamus and the nucleus tractus solitarii in chronic cardiovascular changes associated with anxiety in rats.The Journal of physiology · 2013Article
- Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.Nature neuroscience · 2010Article
- Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin.Molecular psychiatry · 2008Article
- Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.Pharmacology & therapeutics · 2008Review
- Maternal deprivation increases behavioural reactivity to stressful situations in adulthood: suppression by the CCK2 antagonist L365,260.Psychopharmacology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of cholecystokinin (CCK) in the mechanisms of stress and/or anxiety was assessed by in vivo microdialysis in rats subjected to a social stress paradigm. During the initial 30 min period of each conditioning session, a male Sprague Dawley rat (intruder) was placed in a protective cage inside the cage of a male Tryon Maze Dull rat (resident), allowing unrestricted visual, olfactory, and auditory contacts but precluding close physical contact between them. During the following 15 min period, both the protective cage and the resident were removed (nondefeated intruders) or only the protective cage was removed allowing the resident to attack the intruder (defeated rats). This procedure was repeated once daily for 4 d. On the fifth day, a guide cannula was implanted into the prefrontal cortex of intruders. During a single 30 min test session, performed 4 d later, intruders were subjected to only the 30 min protected confrontation to the resident. Anxiety-like behavior (immobility, ultrasonic vocalizations, and defensive postures), associated with an increase (approximately +100% above baseline) in cortical outflow of CCK-like material (CCKLM), were observed in defeated intruders. Pretreatment with diazepam (5 mg/kg, i.p.), but not buspirone (0.5-2 mg/kg, i.p.), prevented both the anxiety-related behavior and CCKLM overflow. The selective CCK-B receptor antagonist CI-988 (2 mg/kg, i.p.) reduced the anxiety-like behavior without affecting the increase in CCKLM outflow. These data indicate that anticipation of social defeat induces a marked activation of cortical CCKergic neurons associated with anxiety-related behaviors in rats.
Indexed as
Identifiers
11150343PMC6762450W1608898322What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.