ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
The contribution of dendritic Kv3 K+ channels to burst threshold in a sensory neuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance.Physiological reviews · 2017Review
- The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation.BMC genomics · 2015Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Functional effects of spinocerebellar ataxia type 13 mutations are conserved in zebrafish Kv3.3 channels.BMC neuroscience · 2010Article
- Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Review
- A C-terminal domain directs Kv3.3 channels to dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- High-threshold K+ current increases gain by offsetting a frequency-dependent increase in low-threshold K+ current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Releasing the peri-neuronal net to patch-clamp neurons in adult CNS.Pflugers Archiv : European journal of physiology · 2004Article
- A dynamic dendritic refractory period regulates burst discharge in the electrosensory lobe of weakly electric fish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Ionic and neuromodulatory regulation of burst discharge controls frequency tuning.Journal of physiology, ParisReview
- Ghostbursting: a novel neuronal burst mechanism.Journal of computational neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated ion channels localized to dendritic membranes can shape signal processing in central neurons. This study describes the distribution and functional role of a high voltage-activating K(+) channel in the electrosensory lobe (ELL) of an apteronotid weakly electric fish. We identify a homolog of the Kv3.3 K(+) channel, AptKv3.3, that exhibits a high density of mRNA expression and immunolabel that is distributed over the entire soma-dendritic axis of ELL pyramidal cells. The kinetics and pharmacology of native K(+) channels recorded in pyramidal cell somata and apical dendrites match those of AptKv3.3 channels expressed in a heterologous expression system. The functional role of AptKv3.3 channels was assessed using focal drug ejections in somatic and dendritic regions of an in vitro slice preparation. Local blockade of AptKv3.3 channels slows the repolarization of spikes in pyramidal cell somata as well as spikes backpropagating into apical dendrites. The resulting increase in dendritic spike duration lowers the threshold for a gamma-frequency burst discharge that is driven by inward current associated with backpropagating dendritic spikes. Thus, dendritic AptKv3.3 K(+) channels influence the threshold for a form of burst discharge that has an established role in feature extraction of sensory input.
Indexed as
Identifiers
11150328PMC6762436W2128362882What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.