ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 110 citations in OpenAlex.
- BDNF Overexpression Enhances Neuronal Activity and Axonal Growth in Human iPSC-Derived Neural Cultures.International journal of molecular sciences · 2025Article
- Article
- hESC-derived striatal progenitors grafted into a Huntington's disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum.Stem cell research & therapy · 2023Article
- REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.eLife · 2021Article
- Autophagy and apoptosis cascade: which is more prominent in neuronal death?Cellular and molecular life sciences : CMLS · 2021Review
- Deletion of BDNF in Pax2 Lineage-Derived Interneuron Precursors in the Hindbrain Hampers the Proportion of Excitation/Inhibition, Learning, and Behavior.Frontiers in molecular neuroscience · 2021Article
- BDNF Expression in Cortical GABAergic Interneurons.International journal of molecular sciences · 2020Article
- Article
- Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of chronic low- and high-dose nicotine on cognitive flexibility in C57BL/6J mice.Behavioural brain research · 2013Article
- Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats.The Journal of comparative neurology · 2012Article
- Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions.Neuroscience · 2011Article
- The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use.Brain research · 2011Article
- BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.Gene therapy · 2010Article
- A role for p11 in the antidepressant action of brain-derived neurotrophic factor.Biological psychiatry · 2010Article
- Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.Journal of neurochemistry · 2010Review
- 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.Molecules (Basel, Switzerland) · 2010Review
- Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.Human molecular genetics · 2008Article
- Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington's disease.Experimental brain research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in BDNF expression after different types of brain insults are related to neuroprotection, stimulation of sprouting, and synaptic reorganization. In the cerebral cortex, an autocrine-paracrine mechanism for BDNF has been proposed because the distribution patterns of BDNF and TrkB expression are almost identical. Moreover, cortical BDNF is anterogradely transported to the striatum, suggesting a role of BDNF in the functional interaction between the two brain regions. Here we have examined the expression of this neurotrophin in the cerebral cortex after various striatal lesions. Intrastriatal injection of quinolinate, kainate, 3-nitropropionic acid, or colchicine increased BDNF mRNA levels in cerebral cortex. In contrast, stimulation of neuronal activity in the striatum did not change cortical BDNF expression. Both excitatory amino acids increased BDNF expression in neurons of cortical layers II/III, V, and VI that project to the striatum. Moreover, grafting a BDNF-secreting cell line prevented both the loss of striatal neurons and the cortical upregulation of BDNF induced by excitotoxins. Because retrograde transport in the corticostriatal pathway was intact after striatal lesions, our results suggest that striatal damage upregulates endogenous BDNF in corticostriatal neurons by a transneuronal mechanism, which may constitute a protective mechanism for striatal and/or cortical cells.
Indexed as
Identifiers
11150327PMC6762434W1576672022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.