ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein [beta] and [delta] Co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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Who cites it
73 citing papers in PubMed, 178 citations in OpenAlex.
- The effects of L-amphetamine sulfate on cognition in MS patients: results of a randomized controlled trial.Journal of neurology · 2009Trial
- A comparative analysis of serum biochemistry, gene expression, and gut microbiota in domestication-susceptible and domestication-resistant mandarin fish (Siniperca chuatsi).Fish physiology and biochemistry · 2026Article
- Hippocampal astrocytic GAT-3 blockade impairs protein synthesis and spatial memory dynamics.Communications biology · 2026Article
- Multiple changes in connectivity between buccal ganglia mechanoafferents and motor neurons with different functions after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Biomarkers in the Rat Hippocampus and Peripheral Blood for an Early Stage of Mental Disorders Induced by Water Immersion Stress.International journal of molecular sciences · 2023Article
- The "Janus" Role of C/EBPs Family Members in Cancer Progression.International journal of molecular sciences · 2020Review
- CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein.Cell death and differentiation · 2020Article
- The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory.Neurobiology of learning and memory · 2019Review
- Influence of isoflurane exposure in pregnant rats on the learning and memory of offsprings.BMC anesthesiology · 2018Article
- Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.Progress in molecular biology and translational science · 2018Review
- Neural, Cellular and Molecular Mechanisms of Active Forgetting.Frontiers in systems neuroscience · 2018Review
- CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.Scientific reports · 2017Article
- CREB, cellular excitability, and cognition: Implications for aging.Behavioural brain research · 2017Review
- Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Spatial genome organization and cognition.Nature reviews. Neuroscience · 2016Review
- Role of hippocampal activity-induced transcription in memory consolidation.Reviews in the neurosciences · 2016Review
- Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB.Neural plasticity · 2016Review
- Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.PloS one · 2015Article
- The regulation of transcription in memory consolidation.Cold Spring Harbor perspectives in biology · 2014Review
- Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences.Neurobiology of learning and memory · 2014Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cAMP response element-binding protein (CREB) is an evolutionarily conserved transcription regulator essential for long-term memory formation. It is not known, however, whether the molecular events downstream of CREB activation are also conserved. An early, cAMP-dependent event necessary for learning-related long-term synaptic plasticity in the invertebrate Aplysia californica is the induction of the transcription factor CCAAT enhancer-binding protein (C/EBP). Here we show that two homologs in the rat, C/EBPbeta and C/EBPdelta, are induced at discrete times after inhibitory avoidance learning and co-localize with phosphorylated CREB in the hippocampus. This induction is blocked by fornix lesions, which are known to disrupt activation of CREB in the hippocampus and to impair memory consolidation. These results indicate that C/EBPs are evolutionarily conserved components of the CREB-dependent gene cascade activated in long-term memory.
Indexed as
Identifiers
11150323PMC6762431W1946757792What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.