ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of transcription regulatory factors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
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- Expression ofAsian-Australasian journal of animal sciences · 2017Article
- Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells.PloS one · 2017Article
- RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction.Biological chemistry · 2016Review
- Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation.Frontiers in genetics · 2016Article
- Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor.The Journal of biological chemistry · 2015Article
- RAFting the rapids of axon regeneration signaling.Neural regeneration research · 2015Article
- Ephrin-A5 suppresses neurotrophin evoked neuronal motility, ERK activation and gene expression.PloS one · 2011Article
- Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.PloS one · 2011Article
- Serum response factor mediated gene activity in physiological and pathological processes of neuronal motility.Frontiers in molecular neuroscience · 2011Article
- Article
- Docosahexaenoic acid significantly stimulates immediate early response genes and neurite outgrowth.Neurochemical research · 2009Article
- Abnormal sympathetic nervous system development and physiological dysautonomia in Egr3-deficient mice.Development (Cambridge, England) · 2008Article
- The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.Oncogene · 2008Article
- Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- A dominant negative inhibitor of the Egr family of transcription regulatory factors suppresses cerebellar granule cell apoptosis by blocking c-Jun activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- BMP enhances transcriptional responses to NGF during PC12 cell differentiation.Neurochemical researchArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although it is well established that members of the Egr family of transcription regulatory factors are induced in many neuronal plasticity paradigms, it is still unclear what role, if any, they play in this process. Because NGF stimulation of pheochromocytoma 12 cells elicits a robust induction of Egr family members, we have investigated their role in mediating long-term effects elicited by NGF in these cells by using the Egr zinc finger DNA-binding domain as a selective antagonist of Egr family-mediated transcription. We report that expression of this Egr inhibitor construct suppresses neurite outgrowth elicited by NGF but not by dibutyryl cAMP. To check that this Egr inhibitor construct does not act by blocking the MEK/ERK pathway, which is known to mediate NGF-induced neurite outgrowth, we confirmed that the Egr inhibitor construct does not block NGF activation of Elk1-mediated transcription, a response that is dependent on this pathway. Conversely, inhibition of MEK does not impair Egr family-mediated transcription. Thus, we conclude (1) that induction of Egr family members and activation of the MEK/ERK pathway by NGF are mediated by separate signaling pathways and (2) that both are required to trigger neurite outgrowth induced by NGF.
Indexed as
Identifiers
11150318PMC6762448W2123398106What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.