ArticleProceedings of the National Academy of Sciences of the United States of America2001
A mechanism for combinatorial regulation of electrical activity: Potassium channel subunits capable of functioning as Src homology 3-dependent adaptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- c-Src Is Responsible for Mitochondria-Mediated Arrhythmic Risk in Ischemic Cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2024Article
- A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis.International journal of molecular sciences · 2021Review
- Extracellular redox sensitivity of Kv1.2 potassium channels.Scientific reports · 2017Article
- Sphingolipids: membrane microdomains in brain development, function and neurological diseases.Open biology · 2017Review
- Use-dependent activation of neuronal Kv1.2 channel complexes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators.PloS one · 2013Article
- Expanded functional diversity of shaker K(+) channels in cnidarians is driven by gene expansion.PloS one · 2012Article
- PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells.Proteomics · 2008Article
- Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.Journal of cell science · 2008Article
- Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Neurotrophin B receptor kinase increases Kv subfamily member 1.3 (Kv1.3) ion channel half-life and surface expression.Neuroscience · 2007Article
- Stress-induced corneal epithelial apoptosis mediated by K+ channel activation.Progress in retinal and eye research · 2006Review
- Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins.Journal of cardiovascular pharmacology · 2006Article
- Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Association/dissociation of a channel-kinase complex underlies state-dependent modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel.Molecular biology of the cell · 2004Article
- Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is an open question how ion channel subunits that lack protein-protein binding motifs become targeted and covalently modified by cellular signaling enzymes. Here, we show that Src-family protein tyrosine kinases (PTKs) bind to heteromultimeric Shaker-family voltage-gated potassium (Kv) channels by interactions between the Src homology 3 (SH3) domain and the proline-rich SH3 domain ligand sequence in the Shaker-family subunit Kv1.5. Once bound to Kv1.5, Src-family PTKs phosphorylate adjacent subunits in the Kv channel heteromultimer that lack proline-rich SH3 domain ligand sequences. This SH3-dependent tyrosine phosphorylation contributes to significant suppression of voltage-evoked currents flowing through the heteromultimeric channel. These results demonstrate that Kv1.5 subunits function as SH3-dependent adaptor proteins that marshal Src-family kinases to heteromultimeric potassium channel signaling complexes, and thereby confer functional sensitivity upon coassembled channel subunits that are themselves not bound directly to Src-family kinases by allowing their phosphorylation. This is a mechanism for information transfer between subunits in heteromultimeric ion channels that is likely to underlie the generation of combinatorial signaling diversity in the control of cellular electrical excitability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.