ArticleProceedings of the National Academy of Sciences of the United States of America2001
Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon.bioRxiv : the preprint server for biology · 2026Article
- Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy.Biomedicines · 2025Review
- Innate immunological memory: from plants to animals.Current opinion in immunology · 2020Review
- Fish Immunoglobulins.Biology · 2016Review
- Two Virus-Induced MicroRNAs Known Only from Teleost Fishes Are Orthologues of MicroRNAs Involved in Cell Cycle Control in Humans.PloS one · 2015Article
- Article
- Functional and structural profiling of the human thrombopoietin gene promoter.The Journal of biological chemistry · 2008Article
- Reconstructing immune phylogeny: new perspectives.Nature reviews. Immunology · 2005Review
- Variable domains and a VpreB-like molecule are present in a jawless vertebrate.Immunogenetics · 2005Article
- Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark.BMC immunology · 2004Article
- Spi-B can functionally replace PU.1 in myeloid but not lymphoid development.The EMBO journal · 2002Article
- Mapping of complex regulatory elements by pufferfish/zebrafish transgenesis.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The phylogenetic placement of chondrichthyes: inferences from analysis of multiple genes and implications for comparative studies.Genetica · 2001Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
T lymphocytes and B lymphocytes are present in jawed vertebrates, including cartilaginous fishes, but not in jawless vertebrates or invertebrates. The origins of these lineages may be understood in terms of evolutionary changes in the structure and regulation of transcription factors that control lymphocyte development, such as PU.1. The identification and characterization of three members of the PU.1 family of transcription factors in a cartilaginous fish, Raja eglanteria, are described here. Two of these genes are orthologs of mammalian PU.1 and Spi-C, respectively, whereas the third gene, Spi-D, is a different family member. In addition, a PU.1-like gene has been identified in a jawless vertebrate, Petromyzon marinus (sea lamprey). Both DNA-binding and transactivation domains are highly conserved between mammalian and skate PU.1, in marked contrast to lamprey Spi, in which similarity is evident only in the DNA-binding domain. Phylogenetic analysis of sequence data suggests that the appearance of Spi-C may predate the divergence of the jawed and jawless vertebrates and that Spi-D arose before the divergence of the cartilaginous fish from the lineage leading to the mammals. The tissue-specific expression patterns of skate PU.1 and Spi-C suggest that these genes share regulatory as well as structural properties with their mammalian orthologs.
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