ArticleProceedings of the National Academy of Sciences of the United States of America2001
Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Proportion, Function, and Generation of Dual Receptor Lymphocytes.Journal of immunology research · 2026Review
- PKC isoforms in hematopoietic lineages and myeloid/lymphoid leukemias: mechanistic insights and therapeutic prospects.Frontiers in oncology · 2026Review
- scRNA-seq revealed the special TCR β & α V(D)J allelic inclusion rearrangement and the high proportion dual (or more) TCR-expressing cells.Cell death & disease · 2023Article
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.Molecular and cellular biology · 2015Article
- Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.Nature communications · 2014Article
- PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.Immunology letters · 2013Article
- Involvement of distinct PKC gene products in T cell functions.Frontiers in immunology · 2012Article
- Critical roles of the PI3K/Akt signaling pathway in T cell development.Immunology letters · 2008Review
- A survival guide to early T cell development.Immunologic research · 2006Review
- TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage.British journal of haematology · 2006Article
- The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.The Journal of experimental medicine · 2005Article
- Emerging and diverse roles of protein kinase C in immune cell signalling.The Biochemical journal · 2003Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Pre-T cell receptor (preTCR)-derived signals mediate the transition of thymocytes from the CD4(-) CD8(-) double-negative (DN) to CD4(+) CD8(+) double-positive stage of T lymphocyte development. This progression, termed beta-selection, is limited to thymocytes that have generated a functional TCR-beta chain able to associate with pTalpha to form the preTCR complex. Formation of the preTCR complex not only induces differentiation, survival, and proliferation of DN thymocytes; it also inhibits further TCR-beta gene rearrangement through an ill-defined process known as allelic exclusion. The signaling pathways controlling this critical developmental checkpoint have not been characterized. Here we demonstrate that formation of the preTCR complex leads to the activation of protein kinase C (PKC), and that activation of PKC is necessary for the differentiation and expansion of DN thymocytes. Importantly, we also show that allelic exclusion at the TCR-beta gene loci is enforced by PKC-mediated signals. These results define PKC as a central mediator of both differentiation and allelic exclusion during thymocyte development.
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