ArticleThe Journal of experimental medicine2001
The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Article
- Peptide-specific natural killer cell receptors.Oxford open immunology · 2025Review
- Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.bioRxiv : the preprint server for biology · 2024Article
- Cutting Edge: Inhibition of the Interaction of NK Inhibitory Receptors with MHC Class I Augments Antiviral and Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Natural killer cell licensing in mice with inducible expression of MHC class I.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Contrasting effects of anti-Ly49A due to MHC class I cis binding on NK cell-mediated allogeneic bone marrow cell resistance.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Targeting of a natural killer cell receptor family by a viral immunoevasin.Nature immunology · 2013Article
- Cis-trans interactions of cell surface receptors: biological roles and structural basis.Cellular and molecular life sciences : CMLS · 2011Review
- Recognition of class I MHC by a rat Ly49 NK cell receptor is dependent on the identity of the P2 anchor amino acid of bound peptide.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Unifying concepts of MHC-dependent natural killer cell education.Trends in immunology · 2011Review
- Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Effects of MHC class I alleles on licensing of Ly49A+ NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Molecular basis for E-cadherin recognition by killer cell lectin-like receptor G1 (KLRG1).The Journal of biological chemistry · 2009Article
- Essential role of the Ly49A stalk region for immunological synapse formation and signaling.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- High allelic polymorphism, moderate sequence diversity and diversifying selection for B-NK but not B-lec, the pair of lectin-like receptor genes in the chicken MHC.Immunogenetics · 2008Article
- Cis interactions of immunoreceptors with MHC and non-MHC ligands.Nature reviews. Immunology · 2008Review
- Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.Seminars in immunology · 2006Review
- Crystal structure of the murine cytomegalovirus MHC-I homolog m144.Journal of molecular biology · 2006Article
- Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity.The Journal of experimental medicine · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells express receptors that recognize major histocompatibility complex (MHC) class I molecules and regulate cytotoxicity of target cells. In this study, we demonstrate that Ly49A, a prototypical C-type lectin-like receptor expressed on mouse NK cells, requires species-specific determinants on beta2-microglobulin (beta2m) to recognize its mouse MHC class I ligand, H-2D(d). The involvement of beta2m in the interaction between Ly49A and H-2D(d) is also demonstrated by the functional effects of a beta2m-specific antibody. We also define three residues in alpha1/alpha2 and alpha3 domains of H-2D(d) that are critical for the recognition of H-2D(d) on target cells by Ly49A. In the crystal structure of the Ly49A/H-2D(d) complex, these residues are involved in hydrogen bonding to Ly49A in one of the two potential Ly49A binding sites on H-2D(d). These data unambiguously indicate that the functional effect of Ly49A as an MHC class I-specific NK cell receptor is mediated by binding to a concave region formed by three structural domains of H-2D(d), which partially overlaps the CD8 binding site.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.