ArticleNature cell biology2000
Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.
Article in Nature cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- The influences of genetic polymorphisms in three candidate genes on the athletic performance of Korean athletes.Genes & genomics · 2025Article
- Article
- HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.Autophagy · 2021Article
- Differential HFE gene expression is regulated by alternative splicing in human tissues.PloS one · 2011Article
- Arsenic interactions with lipid particles containing iron.Environmental geochemistry and health · 2009Article
- Recent advances in understanding haemochromatosis: a transition state.Journal of medical genetics · 2004Review
- Manipulation of iron to determine survival: competition between host and pathogen.Immunologic research · 2004Review
- Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Haemochromatosis.Gut · 2003Review
- The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.The Biochemical journal · 2003Article
- Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- IgG transcytosis and recycling by FcRn expressed in MDCK cells reveals ligand-induced redistribution.The EMBO journal · 2002Article
Corrections and comments
- Retraction · 2003-07-01Error in Results and/or Conclusions · Falsification/Fabrication of Image · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · NIH Misconduct finding for Tirunelveli S Ramalingam https://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-053.html
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- Retracted
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin receptor (TfR). Here we show that wild-type HFE and TfR localize in endosomes and at the basolateral membrane of a polarized duodenal epithelial cell line, whereas the primary haemochromatosis HFE mutant, and another mutant with impaired TfR-binding ability accumulate in the ER/Golgi and at the basolateral membrane, respectively. Levels of the iron-storage protein ferritin are greatly reduced and those of TfR are slightly increased in cells expressing wild-type HFE, but not in cells expressing either mutant. Addition of an endosomal-targeting sequence derived from the human low-density lipoprotein receptor (LDLR) to the TfR-binding-impaired mutant restores its endosomal localization but not ferritin reduction or TfR elevation. Thus, binding to TfR is required for transport of HFE to endosomes and regulation of intracellular iron homeostasis, but not for basolateral surface expression of HFE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.