ReviewDrug safety2000
Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment.
Review in Drug safety, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- The Synergistic and Chimeric Mechanism of Bacteriophage Endolysins: Opportunities for Application in Biotherapeutics, Food, and Health Sectors.Probiotics and antimicrobial proteins · 2025Review
- Advancing drug safety in psychiatry: insights from pharmacogenomics of hypersensitivity reactions.Frontiers in pharmacology · 2025Review
- Factors associated with hematological adverse reactions of drugs authorized via the centralized procedure.Scientific reports · 2024Article
- Mixed T Helper1/T Helper2/T Cytotoxic Profile in Subjects with Chronic Chagas Disease with Hypersensitivity Reactions to Benznidazole.Microbiology spectrum · 2022Article
- Drug-Induced Idiosyncratic Agranulocytosis - Infrequent but Dangerous.Frontiers in pharmacology · 2021Review
- Fluorescent BAPAD Dendrimeric Antigens Are Efficiently Internalized by Human Dendritic Cells.Polymers · 2016Article
- Basophil Reactivity as Biomarker in Immediate Drug Hypersensitivity Reactions-Potential and Limitations.Frontiers in pharmacology · 2016Review
- Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.PloS one · 2016Article
- Discovery of Azurin-Like Anticancer Bacteriocins from Human Gut Microbiome through Homology Modeling and Molecular Docking against the Tumor Suppressor p53.BioMed research international · 2016Article
- Article
- Identification & Characterization of lactobacillus salavarius bacteriocins and its relevance in cancer therapeutics.Bioinformation · 2012Article
- Delayed drug hypersensitivity: models of T-cell stimulation.British journal of clinical pharmacology · 2011Review
- Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2010Review
- Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
- Mechanisms of drug-induced allergy.Mayo Clinic proceedings · 2009Review
- The p-i Concept: Pharmacological Interaction of Drugs With Immune Receptors.The World Allergy Organization journal · 2008Article
- Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions.The AAPS journal · 2006Review
- Role of bioactivation in drug-induced hypersensitivity reactions.The AAPS journal · 2006Review
- Captopril-induced bilateral parotid and submandibular sialadenitis.European journal of clinical pharmacology · 2004Article
- Clinical pharmacology: special safety considerations in drug development and pharmacovigilance.Drug safety · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse drug reactions account for between 2 to 5% of all hospital admissions and can prevent the administration of an otherwise effective therapeutic agent. Hypersensitivity or immune-mediated reactions, although less common, tend to be proportionately more serious. There is convincing evidence to implicate the immune system in the pathogenesis of hypersensitivity reactions. Our understanding of the way in which the immune system recognises drugs is based on the hapten hypothesis; the onset of hypersensitivity involves drug bioactivation, covalent binding to proteins, followed by uptake, antigen processing and T cell proliferation. Central to this hypothesis is the critical role of drug metabolism, with the balance between metabolic bioactivation and detoxification being one important component of individual susceptibility. The purpose of this review is to classify drug hypersensitivity reactions in terms of their clinical presentation, and also to consider recent advances in our understanding of the chemical, biochemical and, in particular, cellular immunological mechanisms of hypersensitivity. The following topics are reviewed: (i) drug disposition and cellular metabolism; (ii) mechanisms of antigen processing and presentation; (iii) the role of cytokines and co-stimulatory molecules in the induction and maintenance of a polarised immune response; and (iv) the application of the hapten hypothesis, danger hypothesis and serial triggering model to drug hypersensitivity. A greater understanding of the mechanism(s) of hypersensitivity may identify novel therapeutic strategies and help to combat one of the more severe forms of adverse reactions to drugs.
Indexed as
Identifiers
11144658What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.