ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Increased prognostic value of combined myocardial perfusion imaging and exercise electrocardiography in patients with coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Incremental prognostic value of combined perfusion and function assessment during myocardial gated SPECT in patients aged 75 years or older.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyTrial
- Prognosis in patients with suspected or known ischemic heart disease and normal myocardial perfusion: long-term outcome and temporal risk variations.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Article
- Myocardial perfusion defects and the left ventricular ejection fraction disclosed by scintigraphy in patients with primary hyperparathyroidism.World journal of surgery · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundMyocardial perfusion imaging (MPI) with technetium-99m-labeled sestamibi and exercise electrocardiography (EECG) are widely used for risk stratification of patients with known or suspected coronary artery disease (CAD). However, no large-scale studies have addressed the prognostic power of the combined information from these diagnostic tools. METHODS AND
resultsWe studied 697 consecutive patients who underwent a 2-day Tc-99m sestamibi cardiac perfusion imaging protocol. The EECG was performed on a bicycle ergometer by symptom-limited exercise. Causes of death were obtained from death certificates. Univariate survival analyses were performed with a Kaplan-Meier estimate and a corresponding log-rank test. A multivariate Cox proportional hazards model was applied to test for potential predictor covariates obtained from hospital records. The predominant risk factors of cardiac death were fixed perfusion defects (relative risk, 2.55; range, 1.43 to 4.55) and an impaired circulatory exercise response (relative risk, 3.26; range, 1.74 to 6.08). The major prognostic information of MPI was the ability to detect patients with a definitively low risk. Patients with impaired circulatory response to exercise test and fixed perfusion defects were at a very high risk.
conclusionThe combined results of MPI and EECG provide substantial information on the long-term risk of cardiac death in patients with suspected CAD.
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