Evidence map›Paper›PMID 11142377›Full record

ArticleRNA (New York, N.Y.)2000

The odyssey of a regulated transcript.

J Vilardell, P Chartrand, R H Singer, J R Warner

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J VilardellDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
P Chartrand
R H Singer
J R Warner
Albert Einstein College of Medicine · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
RIBOSOMAL PROTEIN GENES OF SACCHAROMYCES CEREVISIAER01GM025532 · NIGMS · YESHIVA UNIVERSITY · PI WARNER, JONATHAN R. · 1985 to 2010
$6.2M
RNA TRANSPORT AND LOCALIZATION IN YEAST IN SITUR01GM057071 · NIGMS · YESHIVA UNIVERSITY · PI SINGER, ROBERT H · 1998 to 2019
$5.7M
NCI NIH HHS CA13330NIGMS NIH HHS GM25532NIGMS NIH HHS GM57071
6 · The paper itself

Abstract

The transcript of the Saccharomyces cerevisiae gene, RPL30, is subject to regulated splicing and regulated translation, due to a structure that interacts with its own product, ribosomal protein L30. We have followed the fate of the regulated RPL30 transcripts in vivo. Initially, these transcripts abortively enter the splicing pathway, forming an unusually stable association with U1 snRNP. A large proportion of the unspliced molecules, however, are found in the cytoplasm. Most of these are still bound by L30, as only a small fraction are engaged in translation. Eventually, the unspliced RPL30 transcripts escape the grasp of L30, associate with ribosomes, and fall prey to nonsense mediated decay.

Indexed as

RNA Processing, Post-TranscriptionalBiological TransportCell NucleusCytoplasmFungal ProteinsProtein BiosynthesisRibonucleoprotein, U1 Small NuclearRibosomal ProteinsRNA, FungalRNA, MessengerRNA SplicingSaccharomyces cerevisiaeSpliceosomesTranscription, GeneticFungal ProteinsRibonucleoprotein, U1 Small Nuclearribosomal protein L30Ribosomal ProteinsRNA, FungalRNA, Messenger

Identifiers

PMID11142377
PMCPMC1370047
OpenAlexW2102658213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.