SynthesisBMJ (Clinical research ed.)2001
Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials.
Synthesis in BMJ (Clinical research ed.), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Statins for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2013 · on this mapPooled it
- Systematic review of methods used in meta-analyses where a primary outcome is an adverse or unintended event.BMC medical research methodology · 2012Pooled it
- Statins for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2011 · on this mapPooled it
- Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial.PloS one · 2015Trial
- Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders.Brain and behavior · 2020Article
- Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish.Biology open · 2018Article
- Prevalence of hypobetalipoproteinemia and related psychiatric characteristics in a psychiatric population: results from the retrospective HYPOPSY Study.Lipids in health and disease · 2018Article
- Regulation of monoamine transporters and receptors by lipid microdomains: implications for depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- How lipids may affect risk for suicidal behavior.Journal of psychiatric research · 2018Review
- Effects of Statins and Cholesterol on Patient Aggression: Is There a Connection?Innovations in clinical neuroscience · 2018Article
- Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series.Drug safety - case reports · 2016Article
- Pathways of polyunsaturated fatty acid utilization: implications for brain function in neuropsychiatric health and disease.Brain research · 2015Review
- Lipid correlates of attentional impulsivity in first episode mania: results from an Indian population.Indian journal of psychological medicine · 2014Article
- Benefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - a population with the highest risk of premature coronary artery disease & diabetes.The Indian journal of medical research · 2013Review
- The Relationships between Cholesterol and Suicide: An Update.ISRN psychiatry · 2012Article
- Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence of salt-loading.Nutrition & metabolism · 2010Article
- Controversial role of plant sterol esters in the management of hypercholesterolaemia.European heart journal · 2009Article
- Dental manifestations in bariatric patients: review of literature.Journal of applied oral science : revista FOB · 2009Review
- Lipid-lowering medication use and aggression scores in women: a report from the NHLBI-sponsored WISE study.Journal of women's health (2002) · 2008Article
- Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate the association between cholesterol lowering interventions and risk of death from suicide, accident, or trauma (non-illness mortality).
designMeta-analysis of the non-illness mortality outcomes of large, randomised clinical trials of cholesterol lowering treatments. STUDIES REVIEWED: 19 out of 21 eligible trials that had data available on non-illness mortality. INTERVENTIONS REVIEWED: Dietary modification, drug treatment, or partial ileal bypass surgery for 1-10 years.
main outcome measureDeaths from suicides, accidents, and violence in treatment groups compared with control groups.
resultsAcross all trials, the odds ratio of non-illness mortality in the treated groups, relative to control groups, was 1.18 (95% confidence interval 0.91 to 1.52; P=0.20). The odds ratios were 1.28 (0.94 to 1.74; P=0.12) for primary prevention trials and 1.00 (0.65 to 1.55; P=0.98) for secondary prevention trials. Randomised clinical trials using statins did not show a treatment related rise in non-illness mortality (0.84, 0.50 to 1.41; P=0.50), whereas a trend toward increased deaths from suicide and violence was observed in trials of dietary interventions and non-statin drugs (1.32, 0.98 to 1.77; P=0.06). No relation was found between the magnitude of cholesterol reduction and non-illness mortality (P=0.23).
conclusionCurrently available evidence does not indicate that non-illness mortality is increased significantly by cholesterol lowering treatments. A modest increase may occur with dietary interventions and non-statin drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.