ArticleGenetics2001
Measuring gametic disequilibrium from multilocus data.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A non-threshold region-specific method for detecting rare variants in complex diseases.PloS one · 2017Article
- A multilocus linkage disequilibrium measure based on mutual information theory and its applications.Genetica · 2009Article
- Haplotype block partitioning as a tool for dimensionality reduction in SNP association studies.BMC genomics · 2008Article
- Simultaneous detection of linkage disequilibrium and genetic differentiation of subdivided populations.Genetics · 2004Article
- Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Assessing the performance of the haplotype block model of linkage disequilibrium.American journal of human genetics · 2003Article
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Authors and funding
2 authors.
Funding
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Abstract
We describe a Bayesian approach to analyzing multilocus genotype or haplotype data to assess departures from gametic (linkage) equilibrium. Our approach employs a Markov chain Monte Carlo (MCMC) algorithm to approximate the posterior probability distributions of disequilibrium parameters. The distributions are computed exactly in some simple settings. Among other advantages, posterior distributions can be presented visually, which allows the uncertainties in parameter estimates to be readily assessed. In addition, background knowledge can be incorporated, where available, to improve the precision of inferences. The method is illustrated by application to previously published datasets; implications for multilocus forensic match probabilities and for simple association-based gene mapping are also discussed.
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Registered trials
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