ArticleGenetics2001
Genetic and developmental analysis of X-inactivation in interspecific hybrid mice suggests a role for the Y chromosome in placental dysplasia.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- The role of gonadal hormones and sex chromosomes in sex-dependent effects of early nutrition on metabolic health.Frontiers in endocrinology · 2023Review
- The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Genomic imprinting, disrupted placental expression, and speciation.Evolution; international journal of organic evolution · 2016Article
- Epigenesis and plasticity of mouse trophoblast stem cells.Cellular and molecular life sciences : CMLS · 2016Review
- Sex-Specific Placental Responses in Fetal Development.Endocrinology · 2015Review
- Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.BMC genomics · 2015Article
- A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells.Epigenetics & chromatin · 2015Article
- Parent-of-origin growth effects and the evolution of hybrid inviability in dwarf hamsters.Evolution; international journal of organic evolution · 2014Article
- Lineage-specific regulation of imprinted X inactivation in extraembryonic endoderm stem cells.Epigenetics & chromatin · 2014Article
- Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics.Biology of sex differences · 2013Article
- Chromosome-substituted rat strains provide insights into the genetics of placentation.Physiological genomics · 2011Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
Abstract
It has been shown previously that abnormal placental growth, i.e., hyper- and hypoplasia, occurs in crosses and backcrosses between different mouse (Mus) species. A locus that contributes to this abnormal development has been mapped to the X chromosome. Unexpectedly, an influence of fetal sex on placental development has been observed, in that placentas attached to male fetuses tended to exhibit a more pronounced phenotype than placentas attached to females. Here, we have analyzed this sex dependence in more detail. Our results show that differences between male and female placental weights are characteristic of interspecific matings and are not observed in intraspecific Mus musculus matings. The effect is retained in congenic lines that contain differing lengths of M. spretus-derived X chromosome. Expression of the X-linked gene Pgk1 from the maternal allele only and lack of overall activity of two paternally inherited X-linked transgenes indicate that reactivation or lack of inactivation of the paternal X chromosome in trophoblasts of interspecific hybrids is not a frequent occurrence. Thus, the difference between male and female placentas seems not to be caused by faulty preferential X-inactivation. Therefore, these data suggest that the sex difference of placental weights in interspecific hybrids is caused by interactions with the Y chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.