ArticleGenetics2001
Nucleotide polymorphism and natural selection at the pantophysin (Pan I) locus in the Atlantic cod, Gadus morhua (L.).
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Coexisting Atlantic Cod Ecotypes in the Barents Sea: An Issue for Managing Fisheries.Evolutionary applications · 2026Article
- Mortality drives production dynamics of Atlantic cod through 1100 years of commercial fishing.Science advances · 2025Article
- Sex Influences the Genetic Structure of Greenland Halibut in the North Atlantic.Ecology and evolution · 2025Article
- Article
- Hidden but revealed: After years of genetic studies behavioural monitoring combined with genomics uncover new insight into the population dynamics of Atlantic cod in Icelandic waters.Evolutionary applications · 2023Review
- Unexpected fish and squid in the central Arctic deep scattering layer.Science advances · 2022Article
- The pantophysin gene and its relationship with survival in early life stages of Atlantic cod.Royal Society open science · 2020Article
- Identifying loci under positive selection in complex population histories.Genome research · 2019Article
- Codweb: Whole-genome sequencing uncovers extensive reticulations fueling adaptation among Atlantic, Arctic, and Pacific gadids.Science advances · 2019Article
- Trans-oceanic genomic divergence of Atlantic cod ecotypes is associated with large inversions.Heredity · 2017Article
- Article
- Article
- Fin whale MDH-1 and MPI allozyme variation is not reflected in the corresponding DNA sequences.Ecology and evolution · 2014Article
- Applications in the search for genomic selection signatures in fish.Frontiers in genetics · 2014Review
- Analysis of DNA sequence variation within marine species using Beta-coalescents.Theoretical population biology · 2013Article
- Consequences of fisheries-induced evolution for population productivity and recovery potential.Proceedings. Biological sciences · 2012Article
- Historical changes in genotypic frequencies at the Pantophysin locus in Atlantic cod (Gadus morhua) in Icelandic waters: evidence of fisheries-induced selection?Evolutionary applications · 2011Article
- Complex interplay of evolutionary forces in the ladybird homeobox genes of Drosophila melanogaster.PloS one · 2011Article
- Parallel adaptive evolution of Atlantic cod on both sides of the Atlantic Ocean in response to temperature.Proceedings. Biological sciences · 2010Article
- Integrating the markers Pan I and haemoglobin with the genetic linkage map of Atlantic cod (Gadus morhua).BMC research notes · 2010Article
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1 author.
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Abstract
Molecular studies of nucleotide sequence variation have rarely attempted to test hypotheses related to geographically varying patterns of natural selection. The present study tested the role of spatially varying selection in producing significant linkage disequilibrium and large differences in the frequencies of two common alleles at the pantophysin (Pan I) locus among five populations of the Atlantic cod, Gadus morhua. Nucleotide sequences of 124 Pan I alleles showed strong evidence for an unusual mix of balancing and directional selection but no evidence of stable geographically varying selection. The alleles were highly divergent at both the nucleotide level (differing on average by 19 mutations) and at amino acid level (each having experienced three amino acid substitutions since diverging from a common ancestral allele). All six amino acid substitutions occurred in a 56-residue intravesicular loop (IV1 domain) of the vesicle protein and each involved a radical change. An analysis of molecular variation revealed significant heterogeneity in the frequencies of recently derived mutations segregating within both allelic classes, suggesting that two selective sweeps may be presently occurring among populations. The dynamic nature of the Pan I polymorphism in G. morhua and clear departure from equilibrium conditions invalidate a simple model of spatially varying selection.
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