ArticleGenetics2001
Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- MicroRNAs and metabolic disorders - where are we heading?Archives of medical science : AMS · 2017Article
- Neuronal function of the mRNA decapping complex determines survival ofOpen biology · 2017Article
- Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dampening of expression oscillations by synchronous regulation of a microRNA and its target.Nature genetics · 2013Article
- MicroRNAs in skeletal muscle biology and exercise adaptation.Free radical biology & medicine · 2013Review
- A molt timer is involved in the metamorphic molt in Manduca sexta larvae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets.Genome research · 2012Article
- Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans.Development (Cambridge, England) · 2012Article
- The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.Genes & development · 2011Article
- LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.Current biology : CB · 2010Article
- Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.The Journal of biological chemistry · 2010Article
- Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans.RNA (New York, N.Y.) · 2009Article
- A whole-genome RNAi Screen for C. elegans miRNA pathway genes.Current biology : CB · 2007Article
- The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.Molecular and cellular biology · 2005Article
- Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis.Genetics · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Caenorhabditis elegans heterochronic gene lin-14 specifies the temporal sequence of postembryonic developmental events. lin-14, which encodes differentially spliced LIN-14A and LIN-14B1/B2 protein isoforms, acts at distinct times during the first larval stage to specify first and second larval stage-specific cell lineages. Proposed models for the molecular basis of these two lin-14 gene activities have included the production of functionally distinct isoforms and the generation of a temporal gradient of LIN-14 protein. We report here that loss of the LIN-14B1/B2 isoforms alone affects one of the two lin-14 temporal patterning functions, the specification of second larval stage lineages. A temporal expression difference between LIN-14A and LIN-14B1/B2 is not responsible for the stage-specific phenotype: protein levels of all LIN-14 isoforms are high in early first larval stage animals and decrease during the first larval stage. However, LIN-14A can partially substitute for LIN-14B1/B2 when expressed at a higher-than-normal level in the late L1 stage. These data indicate that LIN-14B1/B2 isoforms do not provide a distinct function of the lin-14 locus in developmental timing but rather may contribute to an overall level of LIN-14 protein that is the critical determinant of temporal cell fate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.