ArticleGenetics2001
A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- sic1 mutation leads to rDNA instability by partial duplication with SIR4.Nucleic acids research · 2026Article
- Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex-Lessons from Transcription-Coupled DNA Damages.International journal of molecular sciences · 2024Review
- Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.The Journal of cell biology · 2018Article
- A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions.Nucleic acids research · 2014Article
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- Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complex.Plant signaling & behavior · 2012Article
- Article
- A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors.The EMBO journal · 2011Article
- New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Molecular and cellular biology · 2011Article
- Yeast Sen1 helicase protects the genome from transcription-associated instability.Molecular cell · 2011Article
- Transcriptional elongation and mRNA export are coregulated processes.Genetics research international · 2011Article
- Assembly of an export-competent mRNP is needed for efficient release of the 3'-end processing complex after polyadenylation.Molecular and cellular biology · 2009Article
- Messenger RNA export from the nucleus: a series of molecular wardrobe changes.Traffic (Copenhagen, Denmark) · 2009Review
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- Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.The Journal of cell biology · 2009Article
- The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.Molecular biology of the cell · 2008Article
- A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.Molecular genetics and genomics : MGG · 2008Article
- The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.The Journal of cell biology · 2008Article
- General, rapid, and transcription-dependent fragmentation of nucleolar antigens in S. cerevisiae mRNA export mutants.RNA (New York, N.Y.) · 2008Article
- SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC.The EMBO journal · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the importance of the incidence of recombination in genomic instability, it is of great interest to know the elements or processes controlling recombination in mitosis. One such process is transcription, which has been shown to induce recombination in bacteria, yeast, and mammals. To further investigate the genetic control of the incidence of recombination and genetic instability and, in particular, its connection with transcription, we have undertaken a search for hyperrecombination mutants among a large number of strains deleted in genes of unknown function. We have identified a new gene, THP1 (YOL072w), whose deletion mutation strongly stimulates recombination between repeats. In addition, thp1 Delta impairs transcription, a defect that is particularly strong at the level of elongation through particular DNA sequences such as lacZ. The hyperrecombination phenotype of thp1 Delta cells is fully dependent on transcription elongation of the repeat construct. When transcription is impeded either by shutting off the promoter or by using a premature transcription terminator, hyperrecombination between repeats is abolished, providing new evidence that transcription-elongation impairment may be a source of recombinogenic substrates in mitosis. We show that Thp1p and two other proteins previously shown to control transcription-associated recombination, Hpr1p and Tho2p, act in the same "pathway" connecting transcription elongation with the incidence of mitotic recombination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.