ArticleGenetics2001
Crossing over is rarely associated with mitotic intragenic recombination in Schizosaccharomyces pombe.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Chromatin organization modulates the origin of heritable structural variations in human genome.Nucleic acids research · 2019Article
- Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq.eLife · 2017Article
- Meiotic versus mitotic recombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are reflected in different pathway usage and different outcomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
- Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.PLoS biology · 2010Article
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- Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Genes & development · 2009Article
- Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe.The EMBO journal · 2008Article
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- Conservative inheritance of newly synthesized DNA in double-strand break-induced gene conversion.Molecular and cellular biology · 2006Article
- The meiotic bouquet promotes homolog interactions and restricts ectopic recombination in Schizosaccharomyces pombe.Genetics · 2006Article
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- Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.Molecular and cellular biology · 2004Article
- The homologous chromosome is an effective template for the repair of mitotic DNA double-strand breaks in Drosophila.Genetics · 2003Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal rearrangements can result from crossing over during ectopic homologous recombination between dispersed repetitive DNA. We have previously shown that meiotic ectopic recombination between artificially dispersed ade6 heteroalleles in the fission yeast Schizosaccharomyces pombe frequently results in chromosomal rearrangements. The same recombination substrates have been studied in mitotic recombination. Ectopic recombination rates in haploids were approximately 1-4 x 10(-6) recombinants per cell generation, similar to allelic recombination rates in diploids. In contrast, ectopic recombination rates in heterozygous diploids were 2.5-70 times lower than allelic recombination or ectopic recombination in haploids. These results suggest that diploid-specific factors inhibit ectopic recombination. Very few crossovers occurred in ade6 mitotic recombination, either allelic or ectopic. Allelic intragenic recombination was associated with 2% crossing over, and ectopic recombination between multiple different pairing partners showed 1-7% crossing over. These results contrast sharply with the 35-65% crossovers associated with meiotic ade6 recombination and suggest either differential control of resolution of recombination intermediates or alternative pathways of recombination in mitosis and meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.