ArticleGenetics2001
The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae.
Article in Genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
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- Hidden Complexity of Yeast Adaptation under Simple Evolutionary Conditions.Current biology : CB · 2018Article
- The Catalytic Activity of the Ubp3 Deubiquitinating Protease Is Required for Efficient Stress Granule Assembly in Saccharomyces cerevisiae.Molecular and cellular biology · 2016Article
- Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation.PLoS genetics · 2014Article
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- Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator.Journal of molecular biology · 2012Article
- Transcriptional profiling of a yeast colony provides new insight into the heterogeneity of multicellular fungal communities.PloS one · 2012Article
- The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.PLoS genetics · 2012Article
- An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy.The Journal of biological chemistry · 2011Article
- The identification and analysis of phosphorylation sites on the Atg1 protein kinase.Autophagy · 2011Article
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- Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.Nucleic acids research · 2008Article
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- Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.Current genetics · 2006Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Saccharomyces cerevisiae cells enter into a distinct resting state, known as stationary phase, in response to specific types of nutrient deprivation. We have identified a collection of mutants that exhibited a defective transcriptional response to nutrient limitation and failed to enter into a normal stationary phase. These rye mutants were isolated on the basis of defects in the regulation of YGP1 expression. In wild-type cells, YGP1 levels increased during the growth arrest caused by nutrient deprivation or inactivation of the Ras signaling pathway. In contrast, the levels of YGP1 and related genes were significantly elevated in the rye mutants during log phase growth. The rye defects were not specific to this YGP1 response as these mutants also exhibited multiple defects in stationary phase properties, including an inability to survive periods of prolonged starvation. These data indicated that the RYE genes might encode important regulators of yeast cell growth. Interestingly, three of the RYE genes encoded the Ssn/Srb proteins, Srb9p, Srb10p, and Srb11p, which are associated with the RNA polymerase II holoenzyme. Thus, the RNA polymerase II holoenzyme may be a target of the signaling pathways responsible for coordinating yeast cell growth with nutrient availability.
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