ArticleThe Journal of physiology2001
Cyclic GMP-dependent relaxation of isolated rat renal glomeruli induced by extracellular ATP.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Functional Metabolomics Analysis Elucidating the Metabolic Biomarker and Key Pathway Change Associated With the Chronic Glomerulonephritis and Revealing Action Mechanism of Rhein.Frontiers in pharmacology · 2020Article
- Extracellular Nucleotides and P2 Receptors in Renal Function.Physiological reviews · 2020Review
- Nitric oxide production by glomerular podocytes.Nitric oxide : biology and chemistry · 2018Article
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells.BMC pharmacology & toxicology · 2013Article
- CONTRACTILITY OF THE RENAL GLOMERULUS AND MESANGIAL CELLS: LINGERING DOUBTS AND STRATEGIES FOR THE FUTURE.Medical hypotheses and research : MHR · 2008Article
- Effects of diadenosine polyphosphates on glomerular volume.British journal of pharmacology · 2005Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relaxing effect of extracellular ATP on renal glomeruli has been investigated by applying ATP and its analogues to suspensions of angiotensin II-precontracted rat renal glomeruli. Based on changes of glomerular [3H]inulin space (GIS) the relaxation of glomeruli was analysed in the presence of agonists: ATP, ADP, AMP, UTP, 2-methylthio-ATP (P2Y agonist), beta,gamma-methylene-ATP (P2X agonist) and adenosine. ATP, 2-methylthio-ATP, ADP and UTP induced concentration-dependent relaxation whereas AMP, beta,gamma-methylene-ATP and adenosine had no effect. The rank order of relaxation potency was 2-methylthio-ATP > ATP > ADP > UTP. An inhibitor of constitutive nitric oxide synthase (NOS), Nomega-nitro-L-arginine (NNA) prevented the ATP-induced increased accumulation of L-citrulline and the relaxation effect of ATP. An inhibitor of the neuronal isoform of NOS, 7-nitroindazole, had no effect on the relaxation effect of ATP. The relaxing effect of ATP was prevented in the presence of inhibitors of cyclic guanylyl cyclase: methylene blue (MB) and the more specific inhibitor 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ). ATP stimulated an accumulation of cGMP that was diminished in the presence of MB. We indicated that extracellular ATP may relax the glomeruli via activation of P2Y receptors with the subsequent activation of the endothelial isoform of nitric oxide synthase and soluble guanylyl cyclase. We suggest that, based on the described mechanism, extracellular ATP may increase the filtration surface which, in turn, may influence the glomerular filtration rate.
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