ArticleThe Journal of physiology2001
Response properties of isolated mouse olfactory receptor cells.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 144 citations in OpenAlex.
- The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026Review
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- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- The CaThe Journal of physiology · 2024Article
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Influence of age on nicotinic cholinergic regulation of blood flow in rat's olfactory bulb and neocortex.The journal of physiological sciences : JPS · 2024Review
- Protein-protein complexes can undermine ultrasensitivity-dependent biological adaptation.Journal of the Royal Society, Interface · 2023Article
- Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding.Science advances · 2022Article
- Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Ultrasensitivity and bistability in covalent-modification cycles with positive autoregulation.Proceedings. Mathematical, physical, and engineering sciences · 2021Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Effects of nicotine on regional blood flow in the olfactory bulb in response to olfactory nerve stimulation.The journal of physiological sciences : JPS · 2020Article
- Emergence of collective oscillations in adaptive cells.Nature communications · 2019Article
- Initial Characterization of a Subpopulation of Inherent Oscillatory Mammalian Olfactory Receptor Neurons.Chemical senses · 2019Article
- Odorant mixtures elicit less variable and faster responses than pure odorants.PLoS computational biology · 2018Article
- Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.Nature communications · 2018Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Energy Requirements of Odor Transduction in the Chemosensory Cilia of Olfactory Sensory Neurons Rely on Oxidative Phosphorylation and Glycolytic Processing of Extracellular Glucose.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Response properties of isolated mouse olfactory receptor cells were investigated using the suction pipette technique. Cells were exposed to the odour cineole or to solutions of modified ionic content by rapidly changing the solution superfusing the cilia. All experiments were performed at 37 degrees C. Mouse olfactory receptor cells displayed a steep dependence of action potential frequency on stimulus concentration, a 3-fold increase in stimulus concentration often saturating the firing frequency at 200-300 Hz. The receptor current increased more gradually with increasing cineole concentration and did not saturate within the 100-fold range of cineole concentrations applied. When stimulated for 30 s with a low odour concentration, cells responded with sporadic spike firing. Higher concentrations led to the generation of a large receptor current at the onset of stimulation which returned to baseline levels within a few seconds, accompanied during its rising phase by a short burst of action potentials. Thereafter an oscillating response pattern was observed during the remainder of the stimulus, consisting of repetitive increases in receptor current of around 1 s duration accompanied by short bursts of action potentials. Olfactory adaptation was studied by comparing the responses to two closely spaced odour stimuli. The response to the second odour stimulus recovered to 80% of its original magnitude when the cell was superfused with Ringer solution during the 5 s interval between odour exposures. In contrast, exposure to a choline-substituted low Na+ solution between odour stimuli had two effects. First, the receptor current response to the first odour stimulus did not terminate as quickly as in the presence of Na+, suggesting the presence of a Na+ -Ca2+ exchanger. Second, the response to the second stimulus only recovered to 55% of its original magnitude, demonstrating the involvement of Na+-Ca2+ exchange in the recovery of sensitivity in mouse olfactory receptor cells following stimulation.
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