ArticleThe Journal of experimental medicine2001
B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 108 citations in OpenAlex.
- The B-cell Receptor Blueprint in Lymphoma: Mechanisms and Therapeutic Opportunities.Blood cancer discovery · 2026Review
- Role of inhibitory signaling in peripheral B cell tolerance.Immunological reviews · 2022Review
- B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages.Journal of translational medicine · 2022Review
- Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice.Scientific reports · 2020Article
- Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.The EMBO journal · 2018Article
- Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Clinical reviews in allergy & immunology · 2017Review
- Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells.PLoS genetics · 2017Article
- Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase.Scientific reports · 2017Article
- CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability.The Journal of experimental medicine · 2015Article
- Article
- B lymphocyte antigen receptor signaling: initiation, amplification, and regulation.F1000prime reports · 2013Review
- Sox4 is required for the survival of pro-B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domain.PloS one · 2013Article
- B-cell receptor pathobiology and targeting in NHL.Current oncology reports · 2012Review
- AUF1 is involved in splenic follicular B cell maintenance.BMC immunology · 2010Article
- Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas.Journal of immunological methods · 2009Article
- The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Article
- Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3.Molecular immunology · 2007Article
- Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization.The Journal of experimental medicine · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The B cell receptor (BCR) regulates B cell development and function through immunoglobulin (Ig)alpha and Ig beta, a pair of membrane-bound Ig superfamily proteins, each of which contains a single cytoplasmic immunoreceptor tyrosine activation motif (ITAM). To determine the function of Ig beta, we produced mice that carry a deletion of the cytoplasmic domain of Ig beta (Ig beta Delta C mice) and compared them to mice that carry a similar mutation in Ig alpha (MB1 Delta C, herein referred to as Ig alpha Delta C mice). Ig beta Delta C mice differ from Ig alpha Delta C mice in that they show little impairment in early B cell development and they produce immature B cells that respond normally to BCR cross-linking as determined by Ca(2+) flux. However, Ig beta Delta C B cells are arrested at the immature stage of B cell development in the bone marrow and die by apoptosis. We conclude that the cytoplasmic domain Ig beta is required for B cell development beyond the immature B cell stage and that Ig alpha and Ig beta have distinct biologic activities in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.