ArticleJournal of clinical microbiology2001
Role of PCR in diagnosis and prognosis of visceral leishmaniasis in patients coinfected with human immunodeficiency virus type 1.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Systematic review of biomarkers to monitor therapeutic response in leishmaniasis.Antimicrobial agents and chemotherapy · 2015Pooled it
- Molecular tools for diagnosis of visceral leishmaniasis: systematic review and meta-analysis of diagnostic test accuracy.Journal of clinical microbiology · 2014Pooled it
- The diagnostic accuracy of serologic and molecular methods for detecting visceral leishmaniasis in HIV infected patients: meta-analysis.PLoS neglected tropical diseases · 2012Pooled it
- Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review.PLoS neglected tropical diseases · 2011Pooled it
- Blood Parasite Load as an Early Marker to Predict Treatment Response in Visceral Leishmaniasis in Eastern Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Trial
- Evaluation of PCR for diagnosis of Indian kala-azar and assessment of cure.Journal of clinical microbiology · 2005Trial
- Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model.PLoS neglected tropical diseases · 2024Article
- Delayed diagnosis among patients with visceral leishmaniasis.Internal and emergency medicine · 2023Observational
- Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study.BMC infectious diseases · 2020Article
- Screening for subclinical Leishmania infection in HIV-infected patients living in eastern Spain.Pathogens and global health · 2014Article
- Ultrasensitive real-time PCR for the clinical management of visceral leishmaniasis in HIV-Infected patients.The American journal of tropical medicine and hygiene · 2013Article
- Diagnosis of visceral leishmaniasis.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2011Review
- Leishmaniases in Northern Greece: seroprevalence of the infection and incidence of the disease during the period 2001-2006.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008Article
- The relationship between leishmaniasis and AIDS: the second 10 years.Clinical microbiology reviews · 2008Review
- Comparison of new diagnostic tools for management of pediatric Mediterranean visceral leishmaniasis.Journal of clinical microbiology · 2006Article
- Leishmaniasis as an opportunistic infection in HIV-infected patients: determinants of relapse and mortality in a collaborative study of 228 episodes in a Mediterreanean region.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2005Article
- Convenience of serum for visceral leishmaniasis diagnosis by PCR.Journal of clinical microbiology · 2004Article
- Real-time PCR assay for clinical management of human immunodeficiency virus-infected patients with visceral leishmaniasis.Journal of clinical microbiology · 2003Article
- Prospective value of PCR amplification and sequencing for diagnosis and typing of old world Leishmania infections in an area of nonendemicity.Journal of clinical microbiology · 2003Article
- Comparison of six PCR methods using peripheral blood for detection of canine visceral leishmaniasis.Journal of clinical microbiology · 2002Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A group of 76 consecutive human immunodeficiency virus (HIV)-positive patients with fever of unknown origin (n = 52) or fever associated with pulmonary diseases was evaluated in order to assess the usefulness of PCR with peripheral blood in the diagnosis and follow-up of visceral leishmaniasis. We identified 10 cases of visceral leishmaniasis among the 52 patients with fever of unknown origin. At the time of diagnosis, all were parasitemic by PCR with peripheral blood. During follow-up, a progressive decline in parasitemia was observed under therapy, and all patients became PCR negative after a median of 5 weeks (range, 6 to 21 weeks). However, in eight of nine patients monitored for a median period of 88 weeks (range, 33 to 110 weeks), visceral leishmaniasis relapsed, with positive results by PCR with peripheral blood reappearing 1 to 2 weeks before the clinical onset of disease. Eight Leishmania infantum and two Leishmania donovani infections were identified by PCR-restriction fragment length polymorphism analysis. PCR with peripheral blood is a reliable method for diagnosis of visceral leishmaniasis in HIV-infected patients. During follow-up, it substantially reduces the need for traditional invasive tests to assess parasitological response, while a positive PCR result is predictive of clinical relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.