ArticleJournal of clinical microbiology2001
Molecular epidemiology of Scedosporium apiospermum infection determined by PCR amplification of ribosomal intergenic spacer sequences in patients with chronic lung disease.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 67 citations in OpenAlex.
- Fungal Pathogens in CF Airways: Leave or Treat?Mycopathologia · 2018Review
- Ecology of Scedosporium Species: Present Knowledge and Future Research.Mycopathologia · 2018Review
- Pathogenesis of Fungal Infections in Cystic Fibrosis.Current fungal infection reports · 2016Review
- Antibiotic management of lung infections in cystic fibrosis. II. Nontuberculous mycobacteria, anaerobic bacteria, and fungi.Annals of the American Thoracic Society · 2014Review
- Impact of multidrug-resistant organisms on patients considered for lung transplantation.Infectious disease clinics of North America · 2013Review
- Article
- Development and validation of a multiplex PCR for detection of Scedosporium spp. in respiratory tract specimens from patients with cystic fibrosis.Journal of clinical microbiology · 2011Article
- Identification of Pseudallescheria and Scedosporium species by three molecular methods.Journal of clinical microbiology · 2011Article
- Clinical significance of microbial infection and adaptation in cystic fibrosis.Clinical microbiology reviews · 2011Review
- Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.Journal of clinical microbiology · 2010Article
- The changing microbial epidemiology in cystic fibrosis.Clinical microbiology reviews · 2010Review
- Detection of occult Scedosporium species in respiratory tract specimens from patients with cystic fibrosis by use of selective media.Journal of clinical microbiology · 2010Article
- Development of an oligonucleotide array for direct detection of fungi in sputum samples from patients with cystic fibrosis.Journal of clinical microbiology · 2009Article
- Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum.Emerging infectious diseases · 2008Article
- Infections caused by Scedosporium spp.Clinical microbiology reviews · 2008Review
- Infection with Scedosporium apiospermum and S. prolificans, Australia.Emerging infectious diseases · 2007Article
- Genotyping study of Scedosporium apiospermum isolates from patients with cystic fibrosis.Journal of clinical microbiology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory tract colonization with Scedosporium apiospermum in patients with chronic suppurative lung disease is a significant concern for lung transplantation candidates, since Scedosporium infections occurring posttransplantation are usually untreatable. Up to 10% of patients with cystic fibrosis attending our respiratory medicine unit have had Scedosporium organisms isolated from sputum samples. We therefore developed a molecular typing method to examine these isolates. Typing by PCR amplification of ribosomal intergenic spacer sequences demonstrated 20 different types from 52 isolates collected from the respiratory medicine unit and elsewhere in Australia. A single common type was isolated from 11 respiratory medicine unit inpatients. Two other types were isolated from more than one source: one from two respiratory medicine unit inpatients and one from two epidemiologically linked nonhuman sources. Multiple isolates were obtained from nine patients. This method demonstrated persistent carriage of isolates of the same type in one patient for 7 months. Two patients showed carriage of isolates with multiple typing patterns within a 3-month period. The high rate of isolation and the predominance of isolates with a single typing pattern from respiratory medicine unit patients may suggest transmission to patients from a source in the unit. There was no epidemiological evidence of direct patient-to-patient spread, and Scedosporium organisms were not isolated from dust, soil, or air samples from the unit. The source and route of transmission have yet to be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.