Trial reportPhysiology & behavior
Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness.
Trial report in Physiology & behavior. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Effects of upper respiratory tract illnesses, ibuprofen and caffeine on reaction time and alertness.Psychopharmacology · 2014Trial
- From Gut to Brain: Probiotics as an Emerging Adjunctive Strategy for Insomnia and Sleep Disturbances.Nature and science of sleep · 2026Review
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection.Neurobiology of sleep and circadian rhythms · 2025Article
- Tapeworm infection affects sleep-like behavior in three-spined sticklebacks.Scientific reports · 2024Article
- Upsetting the Balance: How Modifiable Risk Factors Contribute to the Progression of Alzheimer's Disease.Biomolecules · 2024Review
- Time to Sleep?-A Review of the Impact of the COVID-19 Pandemic on Sleep and Mental Health.International journal of environmental research and public health · 2022Review
- Aromatic ointments for the common cold: what does the science say?Drugs in context · 2022Review
- Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy: Preliminary Assessments of the Role of Sickness, Central and Peripheral Inflammation.Nature and science of sleep · 2021Article
- COVID-19 Infection, the COVID-19 Pandemic, and Changes in Sleep.Frontiers in public health · 2021Article
- Very-Short-Term Sleep Deprivation Slows Early Recovery of Lymphocytes in Septic Patients.Frontiers in medicine · 2021Article
- The Functional Medicine Approach to COVID-19: Nutrition and Lifestyle Practices for Strengthening Host Defense.Integrative medicine (Encinitas, Calif.) · 2020Review
- Fever Dreams: An Online Study.Frontiers in psychology · 2020Article
- A New Hypothesis on Anxiety, Sleep Insufficiency, and Viral Infections; Reciprocal Links to Consider in Today's "World vs. COVID-19" Endeavors.Frontiers in psychiatry · 2020Review
- Sleep and inflammation: partners in sickness and in health.Nature reviews. Immunology · 2019Review
- Sleep during naturally occurring respiratory infections: A pilot study.Brain, behavior, and immunity · 2019Article
- The Sleep-Immune Crosstalk in Health and Disease.Physiological reviews · 2019Review
- Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Perceived Immune Status and Sleep: A Survey among Dutch Students.Sleep disorders · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThere is accumulating evidence that the common cold produces impairments in psychomotor vigilance. This has led some investigators to hypothesize that such illnesses may also have disruptive effects on sleep. While several self-report studies suggest that viral illness may influence sleep parameters, no studies have assessed polysomnographically recorded sleep following viral infections.
designParallel control group comparison.
settingSleep laboratory in a large urban medical center.
participantsTwenty-one men and women with susceptibility to the rhinovirus type 23.
interventionsNasal inoculation with rhinovirus type 23. MEASUREMENTS: Polysomnographically recorded sleep for five nights (2300-0700 h) post-viral inoculation. Twice daily (1030 and 1430 h) performance assessment during each experimental day using auditory vigilance and divided attention tasks. A multiple sleep latency test (MSLT) was performed daily for the duration of the study.
resultsIn symptomatic individuals, total sleep time decreased an average of 23 min, consolidated sleep decreased an average of 36 min, and sleep efficiency was reduced by an average of 5% during the active viral period (experimental days/nights 3-5) compared with the incubation period. Psychomotor performance was impaired. These changes were significantly greater than those observed in asymptomatic individuals.
conclusionsThe common cold can have detrimental effects on sleep and psychomotor performance in symptomatic individuals during the initial active phase of the illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.