ArticleMolecular and cellular biology2001
Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 89 citations in OpenAlex.
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- Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes.Science translational medicine · 2022Article
- Control of ovarian follicle development by TGFβ family signaling.Current opinion in endocrine and metabolic research · 2021Article
- Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice.Science signaling · 2021Article
- Review
- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Article
- DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion.The Journal of cell biology · 2017Article
- Agonists and Antagonists of TGF-β Family Ligands.Cold Spring Harbor perspectives in biology · 2016Review
- Structure of Gremlin-1 and analysis of its interaction with BMP-2.The Biochemical journal · 2016Article
- Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists.The Journal of biological chemistry · 2015Article
- The DAN family: modulators of TGF-β signaling and beyond.Protein science : a publication of the Protein Society · 2014Review
- Article
- Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers.Journal of molecular biology · 2012Article
- A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation.Neuron · 2012Article
- Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes.PloS one · 2012Article
- The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.PloS one · 2011Article
- Animal models of typical heterotopic ossification.Journal of biomedicine & biotechnology · 2011Review
- Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.The Journal of biological chemistry · 2010Article
- Noggin regulates Bmp4 activity during pituitary induction.Developmental biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Dan family of transforming growth factor beta antagonists is a large, evolutionarily conserved family of proteins. Little is known about either the specificity of these antagonists or the biological roles of these proteins. We have characterized Dan, the founding member of this family, with regard to both its biochemical specificity and its biological roles. Although DAN is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo. Intriguingly, in developing neurons, Dan mRNA was localized to axons, suggesting a potential role for the DAN protein in axonal outgrowth or guidance. Mice lacking Dan activity were generated by gene targeting and displayed subtle, background-dependent defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.