Evidence map›Paper›PMID 11134322›Full record

ArticleJournal of virology2001

In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.

M Saito, G P Taylor, A Saito, Y Furukawa, K Usuku, J N Weber, M Osame, C R Bangham

Abstract read
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

M SaitoDepartments of Immunology, Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom.
G P Taylor
A Saito
Y Furukawa
K Usuku
J N Weber
M Osame
C R Bangham
Imperial College London · GBKagoshima University · JPInstitute for Medical Informatics and Biostatistics · CH

Funding

Wellcome Trust
6 · The paper itself

Abstract

Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.

Indexed as

Amino Acid MotifsAmino Acid SequenceCD8-Positive T-LymphocytesComplementarity Determining RegionsGene Products, taxHLA-A2 AntigenHTLV-I InfectionsHumansHuman T-lymphotropic virus 1Molecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReverse Transcriptase Polymerase Chain ReactionComplementarity Determining RegionsGene Products, taxHLA-A2 AntigenReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID11134322
PMCPMC114005
OpenAlexW2169880136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.