Evidence map›Paper›PMID 11134097›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2000

The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly.

E Volpi, B Mittendorfer, B B Rasmussen, R R Wolfe

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 211 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 3 syntheses or guidelines pooled it, 450 citations in OpenAlex.

  1. Pooled it
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  3. Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

E VolpiDepartments of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77550, USA.
B Mittendorfer
B B Rasmussen
R R Wolfe
Shriners Hospitals for Children - Galveston · US

Funding

ZOLLINGER-ELLISON SYNDROME AND DUODONAL ULCER DISEASEM01RR000073 · NCRR · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI RAJI, MUKAILA A · 1985 to 2009
$31.3M
UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
UTMB CLAUDE PEPPER OLDER AMERICANS INDEPENDENCE CENTERP60AG017231 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI GOODWIN, JAMES SIMEON · 2000 to 2004
$6.9M
INSULIN AND SARCOPENIA IN THE ELDERLYR01AG018311 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI VOLPI, ELENA · 2000 to 2010
$3.3M
MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLYR01AG015780 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WOLFE, ROBERT R · 1998 to 2002
$729k
NCRR NIH HHS M01 RR000073NCRR NIH HHS M01RR00073NIA NIH HHS AG15780NIA NIH HHS P30 AG024832NIA NIH HHS P60 AG017231NIA NIH HHS P60AG17231NIA NIH HHS R01 AG015780NIA NIH HHS R01 AG018311
6 · The paper itself

Abstract

Muscle mass declines with aging. Amino acids alone stimulate muscle protein synthesis in the elderly. However, mixed nutritional supplementation failed to improve muscle mass. We hypothesized that the failure of nutritional supplements is due to altered responsiveness of muscle protein anabolism to increased amino acid availability associated with endogenous hyperinsulinemia. We measured muscle protein synthesis and breakdown, and amino acid transport in healthy young (30 +/- 3 yr) and elderly (72 +/- 1 yr) volunteers in the basal postabsorptive state and during the administration of an amino acid-glucose mixture, using L-[ring-(2)H(5)]phenylalanine infusion, femoral artery and vein catheterization, and muscle biopsies. Basal muscle amino acid turnover was similar in young and elderly subjects. The mixture increased phenylalanine leg delivery and transport into the muscle in both groups. Phenylalanine net balance increased in both groups (young, -27 +/- 8 to 64 +/- 17; elderly, -16 +/- 4 to 29 +/- 7 nmol/(min.100 mL); P: < 0.0001, basal vs. mixture), but the increase was significantly blunted in the elderly (P: = 0.030 vs. young). Muscle protein synthesis increased in the young, but remained unchanged in the elderly [young, 61 +/- 17 to 133 +/- 30 (P: = 0. 005); elderly, 62 +/- 9 to 70 +/- 14 nmol/(min.100 mL) (P: = NS)]. In both groups, protein breakdown decreased (P: = 0.012) and leg glucose uptake increased (P: = 0.0258) with the mixture. We conclude that the response of muscle protein anabolism to hyperaminoacidemia with endogenous hyperinsulinemia is impaired in healthy elderly due to the unresponsiveness of protein synthesis.

Indexed as

AdultAgedAgingAmino AcidsBlood GlucoseFemaleGlucoseHormonesHumansHyperinsulinismLegMaleMuscle ProteinsMuscle, SkeletalRegional Blood FlowAmino AcidsBlood GlucoseGlucoseHormonesMuscle Proteins

Identifiers

PMID11134097
PMCPMC3192447
OpenAlexW2028767281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.