ArticleApplied and environmental microbiology2001
pH signaling in Sclerotinia sclerotiorum: identification of a pacC/RIM1 homolog.
Article in Applied and environmental microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 262 citations in OpenAlex.
- The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables.Journal of advanced research · 2026Review
- Biochemical potential of Sclerotinia sclerotiorum strains: optimization of enzyme production and the role of oxalic acid in virulence.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Article
- Revealing the early pathogenic mechanisms of Agroatehlia rolfsii in Arachis hypogaea through RNA-seq and identification of ArNIS1-like effectors.BMC plant biology · 2026Article
- Artificial intelligence and biotechnology for smart storage: Quality and safety perspectives in horticultural produce.Current research in food science · 2026Review
- Stress responsive glycosylphosphatidylinositol-anchored protein SsGSP1 contributes toVirulence · 2025Article
- Nano-chitosan-coated, green-synthesized selenium nanoparticles as a novel antifungal agent against Sclerotinia sclerotiorum: in vitro study.Scientific reports · 2025Article
- Revisiting interactions between polygalacturonases and polygalacturonase-inhibiting proteins and their effects on plant health: a review.Frontiers in plant science · 2025Review
- Functional diversification of oxalate decarboxylases in terms of enzymatic activity, morphosporogenesis, stress regulation and virulence inFrontiers in microbiology · 2025Article
- The Good, the Bad, and the Fungus: Insights into the Relationship Between Plants, Fungi, and Oomycetes in Hydroponics.Biology · 2024Review
- CaMicrobiology spectrum · 2024Article
- Article
- The schizotrophic lifestyle of Sclerotinia sclerotiorum.Molecular plant pathology · 2024Review
- Article
- The broad host range pathogen Sclerotinia sclerotiorum produces multiple effector proteins that induce host cell death intracellularly.Molecular plant pathology · 2023Article
- Ena Proteins Respond to PacC-Mediated pH Signaling Pathway and Play a Crucial Role in Patulin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2023Article
- Article
- Review
- Nitrate reductase is required for sclerotial development and virulence ofFrontiers in plant science · 2023Article
- Characterization of Transcriptional Responses to Genomovirus Infection of the White Mold Fungus,Viruses · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sclerotinia sclerotiorum acidifies its ambient environment by producing oxalic acid. This production of oxalic acid during plant infection has been implicated as a primary determinant of pathogenicity in this and other phytopathogenic fungi. We found that ambient pH conditions affect multiple processes in S. sclerotiorum. Exposure to increasing alkaline ambient pH increased the oxalic acid accumulation independent of carbon source, sclerotial development was favored by acidic ambient pH conditions but inhibited by neutral ambient pH, and transcripts encoding the endopolygalacturonase gene pg1 accumulated maximally under acidic culture conditions. We cloned a putative transcription factor-encoding gene, pac1, that may participate in a molecular signaling pathway for regulating gene expression in response to ambient pH. The three zinc finger domains of the predicted Pac1 protein are similar in sequence and organization to the zinc finger domains of the A. nidulans pH-responsive transcription factor PacC. The promoter of pac1 contains eight PacC consensus binding sites, suggesting that this gene, like its homologs, is autoregulated. Consistent with this suggestion, the accumulation of pac1 transcripts paralleled increases in ambient pH. Pac1 was determined to be a functional homolog of PacC by complementation of an A. nidulans pacC-null strain with pac1. Our results suggest that ambient pH is a regulatory cue for processes linked to pathogenicity, development, and virulence and that these processes may be under the molecular regulation of a conserved pH-dependent signaling pathway analogous to that in the nonpathogenic fungus A. nidulans.
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