ReviewTransgenic research2000
Gene targeting in livestock: a preview.
Review in Transgenic research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- CRISPR/Cas9-mediated targeted knock-in of human erythropoietin at the β-casein locus results in lactogenic hormone-responsive expression in HC11 mammary epithelial cells.Scientific reports · 2026Article
- Improvements in Gene Editing Technology Boost Its Applications in Livestock.Frontiers in genetics · 2020Review
- Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk.Scientific reports · 2015Article
- Knock-in of Enhanced Green Fluorescent Protein or/and Human Fibroblast Growth Factor 2 Gene into β-Casein Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein.Asian-Australasian journal of animal sciences · 2014Article
- Establishment and characterization of fetal fibroblast cell lines for generating human lysozyme transgenic goats by somatic cell nuclear transfer.Transgenic research · 2013Article
- Effects of long-term in vitro culturing of transgenic bovine donor fibroblasts on cell viability and in vitro developmental potential after nuclear transfer.In vitro cellular & developmental biology. Animal · 2013Article
- Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs.Scientific reports · 2013Article
- Derivation and characterization of goat fetal fibroblast cells induced with human telomerase reverse transcriptase.In vitro cellular & developmental biology. Animal · 2013Article
- Porcine Knock-in Fibroblasts Expressing hDAF on α-1,3-Galactosyltransferase (GGTA1) Gene Locus.Asian-Australasian journal of animal sciences · 2012Article
- Primary transgenic bovine cells and their rejuvenated cloned equivalents show transgene-specific epigenetic differences.PloS one · 2012Article
- Enhancing gene targeting efficiency in higher plants: rice is on the move.Transgenic research · 2005Review
- Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline.International journal of medical sciences · 2004Article
- Specific genetic modifications of domestic animals by gene targeting and animal cloning.Reproductive biology and endocrinology : RB&E · 2003Review
- Generation of bovine transgenics using somatic cell nuclear transfer.Reproductive biology and endocrinology : RB&E · 2003Review
- A future for transgenic livestock.Nature reviews. Genetics · 2003Review
- Gene transfer in higher animals: theoretical considerations and key concepts.Journal of biotechnology · 2002Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Until recently genetically modified livestock could only be generated by pronuclear injection. The discovery that animals can be cloned by nuclear transfer from cultured somatic cells means that it will now be possible to achieve gene targeting in these species. We discuss current developments in NT, the prospects and technical challenges for introducing targeted changes into the germline by this route, and the types of application for which this new technology will be used.
Indexed as
Identifiers
11131006What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.