ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2000
Roles of Eph receptors and ephrins in segmental patterning.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Potential of Viruses as Environmental Etiological Factors for Non-Syndromic Orofacial Clefts.Viruses · 2024Article
- Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development.Frontiers in cellular neuroscience · 2023Article
- Pigeonetics takes flight: Evolution, development, and genetics of intraspecific variation.Developmental biology · 2017Review
- Convergent Evolution of Head Crests in Two Domesticated Columbids Is Associated with Different Missense Mutations in EphB2.Molecular biology and evolution · 2015Article
- EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.PloS one · 2014Article
- Article
- Parcellation of the thalamus into distinct nuclei reflects EphA expression and function.Gene expression patterns : GEP · 2013Article
- Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons.Neural development · 2012Article
- The genetics of Alzheimer's disease.Scientifica · 2012Review
- Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors.The Journal of cell biology · 2011Article
- Eph/ephrin molecules--a hub for signaling and endocytosis.Genes & development · 2010Review
- Computational model of cell positioning: directed and collective migration in the intestinal crypt epithelium.Journal of the Royal Society, Interface · 2010Article
- Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Boundary cells regulate a switch in the expression of FGF3 in hindbrain rhombomeres.BMC developmental biology · 2009Article
- Coordinated action of N-CAM, N-cadherin, EphA4, and ephrinB2 translates genetic prepatterns into structure during somitogenesis in chick.Current topics in developmental biology · 2008Review
- Can tissue surface tension drive somite formation?Developmental biology · 2007Article
- Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies.Journal of anatomy · 2005Review
- Hox genes and their candidate downstream targets in the developing central nervous system.Cellular and molecular neurobiology · 2005Review
- Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins.Development (Cambridge, England) · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eph receptor tyrosine kinases and their membrane-bound ligands, ephrins, have key roles in patterning and morphogenesis. Interactions between these molecules are promiscuous, but largely fall into two groups: EphA receptors bind to glycosylphosphatidyl inositol-anchored ephrin-A ligands, and EphB receptors bind to transmembrane ephrin-B proteins. Ephrin-B proteins transduce signals, such that bidirectional signalling can occur upon interaction with the Eph receptor. In many tissues, there are complementary and overlapping expression domains of interacting Eph receptors and ephrins. An important role of Eph receptors and ephrins is to mediate cell contact-dependent repulsion, and this has been implicated in the pathfinding of axons and neural crest cells, and the restriction of cell intermingling between hindbrain segments. Studies in an in vitro system show that bidirectional activation is required to prevent intermingling between cell populations, whereas unidirectional activation can restrict cell communication via gap junctions. Recent work indicates that Eph receptors can also upregulate cell adhesion, but the biochemical basis of repulsion versus adhesion responses is unclear. Eph receptors and ephrins have thus emerged as key regulators that, in parallel with cell adhesion molecules, underlie the establishment and maintenance of patterns of cellular organization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.