ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2000
The control of chemotactic cell movement during Dictyostelium morphogenesis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Dictyostelium exhibits PCB-induced impairment of proliferation, development and stress response, emerging as model for conserved environmental toxicity.Scientific reports · 2025Article
- Traveling-wave chemotaxis of neutrophil-like HL-60 cells.Molecular biology of the cell · 2025Article
- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- Network topology and movement cost, not updating mechanism, determine the evolution of cooperation in mobile structured populations.PloS one · 2023Article
- ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation.FEBS open bio · 2022Article
- Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila.Cellular microbiology · 2019Review
- Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.Development (Cambridge, England) · 2018Article
- When Dicty Met Myco, a (Not So) Romantic Story about One Amoeba and Its Intracellular Pathogen.Frontiers in cellular and infection microbiology · 2017Review
- Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene.PloS one · 2016Article
- Tuning active emulsion dynamics via surfactants and topology.The European physical journal. E, Soft matter · 2013Article
- Dictyostelium discoideum SecG interprets cAMP-mediated chemotactic signals to influence actin organization.Cytoskeleton (Hoboken, N.J.) · 2013Article
- Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum.Eukaryotic cell · 2011Article
- The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development.PloS one · 2010Article
- MAP kinases have different functions in Dictyostelium G protein-mediated signaling.Cellular signalling · 2010Article
- DIF-1 induces the basal disc of the Dictyostelium fruiting body.Developmental biology · 2008Article
- Evolution of size and pattern in the social amoebas.BioEssays : news and reviews in molecular, cellular and developmental biology · 2007Review
- Moving forward moving backward: directional sorting of chemotactic cells due to size and adhesion differences.PLoS computational biology · 2006Article
- A cysteine-rich extracellular protein containing a PA14 domain mediates quorum sensing in Dictyostelium discoideum.Eukaryotic cell · 2005Article
- The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.Molecular biology of the cell · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differential cell movement is an important mechanism in the development and morphogenesis of many organisms. In many cases there are indications that chemotaxis is a key mechanism controlling differential cell movement. This can be particularly well studied in the starvation-induced multicellular development of the social amoeba Dictyostelium discoideum. Upon starvation, up to 10(5) individual amoebae aggregate to form a fruiting body The cells aggregate by chemotaxis in response to propagating waves of cAMP, initiated by an aggregation centre. During their chemotactic aggregation the cells start to differentiate into prestalk and prespore cells, precursors to the stalk and spores that form the fruiting body. These cells enter the aggregate in a random order but then sort out to form a simple axial pattern in the slug. Our experiments strongly suggest that the multicellular aggregates (mounds) and slugs are also organized by propagating cAMP waves and, furthermore, that cell-type-specific differences in signalling and chemotaxis result in cell sorting, slug formation and movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.