ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2000
Genetic control of size in Drosophila.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 116 citations in OpenAlex.
- Parallel shifts in differential gene expression reveal convergent miniaturization in fishes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease.Journal of developmental biology · 2023Review
- Phenotypic extremes or extreme phenotypes? On the use of large and small-bodied "phenocopied"Current research in insect science · 2023Article
- Article
- Sex-dependent and sex-independent regulatory systems of size variation in natural populations.Molecular systems biology · 2019Article
- Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia.Developmental cell · 2019Article
- Review
- BMP Signaling Determines Body Size via Transcriptional Regulation of Collagen Genes inGenetics · 2018Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Review
- Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster.Nature communications · 2016Article
- Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster.PLoS genetics · 2016Article
- Compensatory growth in novel Drosophila Akt1 mutants.BMC research notes · 2015Article
- The FlyCatwalk: a high-throughput feature-based sorting system for artificial selection in Drosophila.G3 (Bethesda, Md.) · 2015Article
- Sizing it up: the mechanical feedback hypothesis of organ growth regulation.Seminars in cell & developmental biology · 2014Review
- Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.PloS one · 2014Article
- Article
- A note on the population genetic consequences of delayed larval development in insects.Genetics and molecular biology · 2013Article
- TGF-β signaling in C. elegans.WormBook : the online review of C. elegans biology · 2013Review
- Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.Molecular ecology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past ten years, significant progress has been made in understanding the basic mechanisms of the development of multicellular organisms. Genetic analysis of the development of Caenorhabditis elegans and Drosophila has unearthed a fruitful number of genes involved in establishing the basic body plan, patterning of limbs, specification of cell fate and regulation of programmed cell death. The genes involved in these developmental processes have been conserved throughout evolution and homologous genes are involved in the patterning of insect and human limbs. Despite these important discoveries, we have learned astonishingly little about one of the most obvious distinctions between animals: their difference in body size. The mass of the smallest mammal, the bumble-bee bat, is 2 g while that of the largest mammal, the blue whale, is 150 t or 150 million grams. Remarkably, even though they are in the same class, body size can vary up to 75-million-fold. Furthermore, this body growth can be finite in the case of most vertebrates or it can occur continuously throughout life, as for trees, molluscs and large crustaceans. Currently, we know comparatively little about the genetic control of body size. In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.